in order to explain the bioactivity of different protein for- mulations. We have shown that alteration of the chemical identity, conformation and availability of free binding motifs (GxOGER and RGD), resulting from addition of gelatin to collagen and crosslinking, have a profound effect on the ability of cells to adhere to these formulations. Carbodiimide crosslinking ablates integrin-dependent cell activity on both two-dimensional and three-dimensional architectures while the three-dimensional scaffold structure also leads to a high level of non-speciﬁc interactions remaining on three-dimensional samples even after a 1 Introduction The original version of this article was revised: the copyright was wrong in the PDF version of the article and the Open Access license The extracellular matrix (ECM) of tissues provides terms were missing. mechanical support for cells and supplies correct biological * Natalia Davidenko signals for cell activity [1–4]. When used as cell-delivery firstname.lastname@example.org vehicles in tissue engineering (TE) applications, biopolymer scaffolds should mimic these ECM functions. Biological Department of Materials Science and Metallurgy, University of Cambridge, 27 Charles Babbage Road, Cambridge CB3 0FS, UK performance of three-dimensional (3D) matrices are inﬂu- enced by several parameters such as the nature and avail- Department of Biochemistry, University of Cambridge, Downing Site,
Journal of Materials Science: Materials in Medicine – Springer Journals
Published: Aug 31, 2016
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera