Evaluation of behavior and endocrinological changes after REM sleep deprivation-induced mania-like behavior in mice

Evaluation of behavior and endocrinological changes after REM sleep deprivation-induced... The pressure to stay up longer in our modern society due to constant exposure to artificial light and interactive activities; furthermore, social and economic pressures impact human physiology and behavior. Rapid eye movement sleep deprivation (REMSD) alters most of the hormones, which may have adverse behavioral changes and other health consequences like mania and other psychiatric disorders. The exact role of REMSD-altered hormonal levels and the manner in which emerging consequences lead to mania-like behavior is poorly understood. Thus, we sought to verify the behavior and endocrinological changes after 48, 72, and 96 h of REMSD-induced mania-like behavior in mice. We performed modified multiple platform method of depriving the REM sleep for 48, 72 and 96 h, respectively, and one group maintained as a control. Motor assess- ment and aggressive behavior were determined by IR-Actimeter and Resident Intruder Test. Quantitative determination of serum thyroid hormones (TSH, T4, and T3), testosterone, corticosterone (CORT), prolactin (PRL), adrenocorticotropic hormone (ACTH), oxytocin (OT) and melatonin (MT) concentrations were determined by ELISA method. After respective hours of REMSD, the higher locomotion noticed among all REMSD mice and also showed higher aggressive behavior com- pared with control. Concentration of serum TSH and T4 was declined and elevated http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Sleep and Biological Rhythms Springer Journals

Evaluation of behavior and endocrinological changes after REM sleep deprivation-induced mania-like behavior in mice

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Publisher
Springer Japan
Copyright
Copyright © 2018 by Japanese Society of Sleep Research
Subject
Biomedicine; Human Physiology; Neurology; Neurosciences; Health Psychology; Psychiatry; Internal Medicine
ISSN
1446-9235
eISSN
1479-8425
D.O.I.
10.1007/s41105-018-0166-6
Publisher site
See Article on Publisher Site

Abstract

The pressure to stay up longer in our modern society due to constant exposure to artificial light and interactive activities; furthermore, social and economic pressures impact human physiology and behavior. Rapid eye movement sleep deprivation (REMSD) alters most of the hormones, which may have adverse behavioral changes and other health consequences like mania and other psychiatric disorders. The exact role of REMSD-altered hormonal levels and the manner in which emerging consequences lead to mania-like behavior is poorly understood. Thus, we sought to verify the behavior and endocrinological changes after 48, 72, and 96 h of REMSD-induced mania-like behavior in mice. We performed modified multiple platform method of depriving the REM sleep for 48, 72 and 96 h, respectively, and one group maintained as a control. Motor assess- ment and aggressive behavior were determined by IR-Actimeter and Resident Intruder Test. Quantitative determination of serum thyroid hormones (TSH, T4, and T3), testosterone, corticosterone (CORT), prolactin (PRL), adrenocorticotropic hormone (ACTH), oxytocin (OT) and melatonin (MT) concentrations were determined by ELISA method. After respective hours of REMSD, the higher locomotion noticed among all REMSD mice and also showed higher aggressive behavior com- pared with control. Concentration of serum TSH and T4 was declined and elevated

Journal

Sleep and Biological RhythmsSpringer Journals

Published: Jun 5, 2018

References

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