Evaluation of behavior and endocrinological changes after REM sleep deprivation-induced mania-like behavior in mice

Evaluation of behavior and endocrinological changes after REM sleep deprivation-induced... The pressure to stay up longer in our modern society due to constant exposure to artificial light and interactive activities; furthermore, social and economic pressures impact human physiology and behavior. Rapid eye movement sleep deprivation (REMSD) alters most of the hormones, which may have adverse behavioral changes and other health consequences like mania and other psychiatric disorders. The exact role of REMSD-altered hormonal levels and the manner in which emerging consequences lead to mania-like behavior is poorly understood. Thus, we sought to verify the behavior and endocrinological changes after 48, 72, and 96 h of REMSD-induced mania-like behavior in mice. We performed modified multiple platform method of depriving the REM sleep for 48, 72 and 96 h, respectively, and one group maintained as a control. Motor assessment and aggressive behavior were determined by IR-Actimeter and Resident Intruder Test. Quantitative determination of serum thyroid hormones (TSH, T4, and T3), testosterone, corticosterone (CORT), prolactin (PRL), adrenocorticotropic hormone (ACTH), oxytocin (OT) and melatonin (MT) concentrations were determined by ELISA method. After respective hours of REMSD, the higher locomotion noticed among all REMSD mice and also showed higher aggressive behavior compared with control. Concentration of serum TSH and T4 was declined and elevated the T3, PRL, CORT, testosterone, ACTH, OT and MT levels in REMSD mice. These experiments showed that concentrations for the majority of the studied hormone and behavior were disrupted during REMSD. Our study indicated that REMSD results in mania-like behavior in mice and associated disruption to hormonal levels, although the exact mechanisms by which these take place remain to be determined. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Sleep and Biological Rhythms Springer Journals

Evaluation of behavior and endocrinological changes after REM sleep deprivation-induced mania-like behavior in mice

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Japanese Society of Sleep Research
Subject
Biomedicine; Human Physiology; Neurology; Neurosciences; Health Psychology; Psychiatry; Internal Medicine
ISSN
1446-9235
eISSN
1479-8425
DOI
10.1007/s41105-018-0166-6
Publisher site
See Article on Publisher Site

Abstract

The pressure to stay up longer in our modern society due to constant exposure to artificial light and interactive activities; furthermore, social and economic pressures impact human physiology and behavior. Rapid eye movement sleep deprivation (REMSD) alters most of the hormones, which may have adverse behavioral changes and other health consequences like mania and other psychiatric disorders. The exact role of REMSD-altered hormonal levels and the manner in which emerging consequences lead to mania-like behavior is poorly understood. Thus, we sought to verify the behavior and endocrinological changes after 48, 72, and 96 h of REMSD-induced mania-like behavior in mice. We performed modified multiple platform method of depriving the REM sleep for 48, 72 and 96 h, respectively, and one group maintained as a control. Motor assessment and aggressive behavior were determined by IR-Actimeter and Resident Intruder Test. Quantitative determination of serum thyroid hormones (TSH, T4, and T3), testosterone, corticosterone (CORT), prolactin (PRL), adrenocorticotropic hormone (ACTH), oxytocin (OT) and melatonin (MT) concentrations were determined by ELISA method. After respective hours of REMSD, the higher locomotion noticed among all REMSD mice and also showed higher aggressive behavior compared with control. Concentration of serum TSH and T4 was declined and elevated the T3, PRL, CORT, testosterone, ACTH, OT and MT levels in REMSD mice. These experiments showed that concentrations for the majority of the studied hormone and behavior were disrupted during REMSD. Our study indicated that REMSD results in mania-like behavior in mice and associated disruption to hormonal levels, although the exact mechanisms by which these take place remain to be determined.

Journal

Sleep and Biological Rhythms – Springer Journals

Published: Jun 5, 2018

References

  • The phylogeny of sleep database: a new resource for sleep scientists
    McNamara, P; Capellini, I; Harris, E; Nunn, CL; Barton, RA; Preston, B
  • Insufficient sleep—a population-based study in adults
    Hublin, C; Kaprio, J; Partinen, M; Koskenvuo, M
  • Health in a 24-h society
    Rajaratnam, SM; Arendt, J
  • Quickstats: percentage of adults who reported an average of < 6 hours of sleep per 24-hour period bSaAG-US
  • Sleep and circadian rhythms in bipolar disorder: seeking synchrony, harmony, and regulation
    Harvey, AG
  • Bipolar disorder: advances in psychotherapy-evidence-based practice
    Reiser, R; Thompson, LW
  • The global burden of disease
    Murray, CJ; Lopez, AD
  • Excess mortality in bipolar and Unipolar disorder in Sweden
    Osby, U; Brandt, L; Correia, N; Ekbom, A; Sparen, P
  • Bipolar disorder
    Muller-Oerlinghausen, B; Berghofer, A; Bauer, M
  • Changes in serum TSH and free T4 during human sleep restriction
    Kessler, L; Nedeltcheva, A; Imperial, J; Penev, PD
  • Hypothalamic thyrotropin-releasing hormone mRNA responses to hypothyroxinemia induced by sleep deprivation
    Everson, CA; Nowak, TS
  • Effect of total sleep deprivation on 5-deiodinase activity of rat brown adipose tissue
    Balzano, S; Bergmann, BM; Gilliland, MA; Silva, JE; Rechtschaffen, A; Refetoff, S
  • Thyroid function in different psychiatric disorders
    Boral, GC; Gosh, AB; Pal, SK; Gosh, KK; Nandi, DN
  • Effects of supraphysiologic doses of testosterone on mood and aggression in normal men: a randomized controlled trial
    Pope, HG; Kouri, EM; Hudson, JI
  • Neuropsychiatric effects of anabolic steroids in male normal volunteers
    Su, TP; Pagliaro, M; Schmidt, PJ; Pickar, D; Wolkowitz, O; Rubinow, DR
  • Psychosexual effects of three doses of testosterone cycling in normal men
    Yates, WR; Perry, PJ; MacIndoe, J; Holman, T; Ellingrod, V
  • Testosterone-patch-induced psychotic mania
    Weiss, EL; Bowers, MB; Mazure, CM
  • Increased prolactin concentrations in a patient with bipolar disorder
    Schmidt, M; Sofronescu, A; Short, B; Nahas, Z; Zhu, Y
  • Endocrinological and catecholaminergic alterations during sleep deprivation and recovery in male rats
    Andersen, ML; Martins, PJ; D’Almeida, V; Bignotto, M; Tufik, S
  • Genomic and non-genomic effects of glucocorticoids on aggressive behavior in male rats
    Mikics, E; Kruk, MR; Haller, J
  • Cerebrospinal fluid neurophysins in affective illness and in schizophrenia
    Linkowski, P; Geenen, V; Kerkhofs, M; Mendlewicz, J; Legros, JJ
  • Nucleus accumbens deep-brain stimulation efficacy in ACTH-pretreated rats: alterations in mitochondrial function relate to antidepressant-like effects
    Kim, Y; McGee, S; Czeczor, JK; Czeczor, JK; Walker, AJ; Kale, RP; Kouzani, AZ; Walder, K; Berk, M; Tye, SJ
  • Study of selective deprivation of the paradoxal sleep phase in the cat
    Jouvet, D; Vimont, P; Delorme, F; Jouvet, M
  • Effects of acute and chronic sleep loss on immune modulation of rats
    Zager, A; Andersen, ML; Ruiz, FS; Antunes, IB; Tufik, S
  • Inhibitory effect of asiatic acid on acetylcholinesterase, excitatory post synaptic potential and locomotor activity
    Nasir, MN; Abdullah, J; Habsah, M; Ghani, RI; Rammes, G
  • Social experiences during adolescence affect anxiety-like behavior but not aggressiveness in male mice
    Meyer, N; Jenikejew, J; Richter, SH; Kaiser, S; Sachser, N
  • Effect of lithium chloride on testicular steroidogenesis and gametogenesis in immature male rats
    Ghosh, PK; Biswas, NM; Ghosh, D
  • Magnitude and associated factors of aggressive behaviour among patients with bipolar disorder at A manual Mental Specialized Hospital, outpatient department, Addis Ababa, Ethiopia: cross-sectional study BMC
    Belete, H; Mulat, H; Fanta, T; Yimer, S; Shimelash, T; Ali, T; Tewabe, T
  • Sleep deprivation alters thyroid hormone economy in rats
    Rodrigues, NC; Cruz, NS; Paula Nascimento, C; Conceição, RR; Silva, AC; Olivares, EL; Marassi, MP
  • Thyroid function in different psychiatric disorders
    Boral, GC; Gosh, AB; Pal, SK; Gosh, KK; Nandi, DN
  • Appearance of mania in drug-resistant bipolar depressed patients after treatment with l-triiodothyronine
    Evans, DL; Strawn, SK; Haggerty, JJR; Garbutt, JC; Burnett, GB; Pedersen, CA
  • Is there a neuroendocrinological rationale for testosterone as a therapeutic option in depression?
    Ebinger, M; Sievers, C; Ivan, D; Schneider, HJ; Stalla, GK
  • Sleep deprivation alters pupillary reactivity to emotional stimuli in healthy young adults
    Franzen, PL; Buysse, DJ; Dahl, RE; Thompson, W; Siegle, GJ
  • Sleep deprivation adversely affects interpersonal responses to frustration
    Kahn-Greene, ET; Lipizzim, EL; Conrad, AK; Kamimori, GH; Killgore, WDS
  • Testosterone levels in suicide attempters with bipolar disorder
    Sher, L; Grunebaum, MF; Sullivan, GM; Burke, AK; Cooper, TB; Mann, JJ; Oquendo, MA
  • Plasma testosterone, aggressive behavior, and personality dimensions in young male delinquents
    Mattsson, A; Schalling, D; Olweus, D; Löw, H; Svensson, J
  • Stress-induced insomnia: opioid–dopamine interactions
    Fratta, W; Collu, M; Martellotta, MC; Pichiri, M; Muntoni, F; Gessa, GL
  • Sleep deprivation in the rat: an animal model of mania
    Gessa, GL; Pani, L; Fadda, P; Fratta, W
  • The simultaneous measurement of aldosterone, cortisol, and corticosterone in human peripheral plasma by displacement analysis
    Underwood, RH; Williams, GH
  • Disturbed endocrine function in the psychoses I: disordered homeostasis or disease process?
    Whalley, LJ; Christie, JE; Blackwood, DH; Bennie, J; Dick, H; Blackburn, IM; Fink, G
  • Pharmacological causes of hyperprolactinemia
    Torre, DL; Falorni, A
  • Hyperprolactinemia in antipsychotic naive patients with first-episode psychosis
    Riecher-Rossler, A; Rybakowski, JK; Pflueger, MO; Beyrau, R; Kahn, RS; Malik, P; Fleischhacker, WW
  • Increased prolactin concentrations in a patient with bipolar disorder
    Schmidt, M; Sofronescu, A; Short, B; Nahas, Z; Zhu, Y
  • Concise dictionary of pharmacological agents: properties and synonyms
    Morton, IK; Hall, JM
  • Lithium ameliorates sleep deprivation induced mania-like behavior, hypothalamic-pituitary-adrenal (HPA) axis alterations, oxidative stress and elevations of cytokine concentrations in the brain and serum of mice
    Valvassori, SS; Resende, WR; Dal-Pont, G; Sangaletti-Pereira, H; Gava, FF; Peterle, BR; Carvalho, AF; Varela, RB; Dal-Pizzol, F; Quevedo, J
  • The HPA axis in bipolar disorder: systematic review and meta-analysis
    BelvederiMurri, M; Prestia, D; Mondelli, V; Pariante, C; Patti, S; Olivieri, B; Arzani, C; Masotti, M; Respino, M; Antonioli, M; Vassallo, L; Serafini, G; Perna, G; Pompili, M; Amore, M
  • Sleep deprivation induces abnormal bone metabolism in temporomandibular joint
    Geng, W; Wu, G; Huang, F; Zhu, Y; Nie, J; He, Y; Chen, L
  • Oxytocin pathways and the evolution of human behavior
    Carter, CS
  • May oxytocin be a trait marker for bipolar disorder?
    Turan, T; Uysal, C; Asdemir, A; Kılıç, E
  • Melatonin suppression by light in euthymic bipolar and unipolar patients
    Nurnberger, JI; Adkins, S; Lahiri, DK; Mayeda, A; Hu, K; Lewy, A; Miller, A; Bowman, ES; Miller, MJ; Rau, L; Smiley, C; Davis-Singh, D
  • Melatonin and Cortisol “switches” during mania, depression and euthymia in a drug free bipolar patient
    Kennedy, SH; Tighe, S; McVey, G; Brown, GM

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