An atmospheric pressure chemical ionization (APCI) source designed for microliter-per-minute ﬂow rates (0.5–10.0 mm / min) was constructed. A simple resistively heated 1/8 in. OD tube-based nebulizer, together with a corona-discharge electrode was positioned in front of the entrance capillary of a mass spectrometer. Working parameters of the ion source were optimized, and its performance was evaluated. The limit of detection for directly infused acridine was found to be lower for micro-APCI (10 fmol/s) than for conventional APCI (170 fmol/s), and the linear dynamic range was signiﬁcantly wider for the micro-APCI source. The micro-APCI and conventional APCI sources provided similar, but not identical mass spectra. The micro-APCI source was used as a detector for high-performance liquid chromatography at 10 mm /min; the limit of detection for acridine was 690 fmol, which was about ten times lower value than in conventional HPLC. Graphical abstract Keywords Charge transfer Hydrogen transfer Mass spectroscopy Micro-APCI Tubular nebulizer Introduction Atmospheric pressure chemical ionization (APCI) mass spectrometry is commonly used in LC/MS applications. In Electronic supplementary material The online version of this article contrast to electrospray, the ions are generated from neutral (https://doi.org/10.1007/s00706-018-2172-4) contains supplementary species, which makes the method efﬁcient
Monatshefte für Chemie - Chemical Monthly – Springer Journals
Published: Feb 17, 2018
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