Evaluation of adaptive radiotherapy (ART) by use of replanning the tumor bed boost with repeated computed tomography (CT) simulation after whole breast irradiation (WBI) for breast cancer patients having clinically evident seroma

Evaluation of adaptive radiotherapy (ART) by use of replanning the tumor bed boost with repeated... Purpose The aim of this study is to evaluate adaptive radiotherapy (ART) by use of replanning the tumor bed boost with repeated computed tomography (CT) simulation after whole breast irradiation (WBI) for breast cancer patients having clini- cally evident seroma. Materials and methods Forty-eight patients with clinically evident seroma at the time of planning CT simulation for WBI were included. Two RT treatment plannings were generated for each patient based on the initial CT simulation and tumor bed boost CT simulation to assess seroma and boost target volume (BTV) changes during WBI. Also, dosimetric impact of ART was analyzed by comparative evaluation of critical organ doses in both RT treatment plannings. Results Median time interval between the two CT simulations was 35 days. Statistically significant reduction was detected in seroma volume and BTV during the conventionally fractionated WBI course along with statistically significant reduction in critical organ doses with ART (p < 0.0001). Conclusion Our data suggest significant benefit of ART by use of replanning the tumor bed boost with repeated CT simula - tion after WBI for patients with clinically evident seroma. Keywords Breast cancer · Seroma · Adaptive radiotherapy (ART) · Whole breast irradiation (WBI) · Tumor bed boost Abbreviations Introduction WBI http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Japanese Journal of Radiology Springer Journals

Evaluation of adaptive radiotherapy (ART) by use of replanning the tumor bed boost with repeated computed tomography (CT) simulation after whole breast irradiation (WBI) for breast cancer patients having clinically evident seroma

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Japan Radiological Society
Subject
Medicine & Public Health; Imaging / Radiology; Nuclear Medicine; Radiotherapy
ISSN
1867-1071
eISSN
1867-108X
D.O.I.
10.1007/s11604-018-0735-2
Publisher site
See Article on Publisher Site

Abstract

Purpose The aim of this study is to evaluate adaptive radiotherapy (ART) by use of replanning the tumor bed boost with repeated computed tomography (CT) simulation after whole breast irradiation (WBI) for breast cancer patients having clini- cally evident seroma. Materials and methods Forty-eight patients with clinically evident seroma at the time of planning CT simulation for WBI were included. Two RT treatment plannings were generated for each patient based on the initial CT simulation and tumor bed boost CT simulation to assess seroma and boost target volume (BTV) changes during WBI. Also, dosimetric impact of ART was analyzed by comparative evaluation of critical organ doses in both RT treatment plannings. Results Median time interval between the two CT simulations was 35 days. Statistically significant reduction was detected in seroma volume and BTV during the conventionally fractionated WBI course along with statistically significant reduction in critical organ doses with ART (p < 0.0001). Conclusion Our data suggest significant benefit of ART by use of replanning the tumor bed boost with repeated CT simula - tion after WBI for patients with clinically evident seroma. Keywords Breast cancer · Seroma · Adaptive radiotherapy (ART) · Whole breast irradiation (WBI) · Tumor bed boost Abbreviations Introduction WBI

Journal

Japanese Journal of RadiologySpringer Journals

Published: Apr 5, 2018

References

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