Evaluating the impact of varied compliance to lung cancer screening recommendations using a microsimulation model

Evaluating the impact of varied compliance to lung cancer screening recommendations using a... Cancer Causes Control (2017) 28:947–958 DOI 10.1007/s10552-017-0907-x OR IGINAL PAPER Evaluating the impact of varied compliance to lung cancer screening recommendations using a microsimulation model 1 2 3 4 • • • • Summer S. Han S. Ayca Erdogan Iakovos Toumazis Ann Leung Sylvia K. Plevritis Received: 13 August 2015 / Accepted: 25 May 2017 / Published online: 12 July 2017 Springer International Publishing AG 2017 Abstract outcomes of the lifetime screening program recommended Background The US preventive services task force by the USPSTF by varying screening compliance levels. (USPSTF) recently recommended that individuals aged Results Validation using PLCO shows that our model 55–80 with heavy smoking history be annually screened by reproduces observed PLCO outcomes, predicting 884 LC low-dose computed tomography (LDCT), thereby extend- cases [Expected(E)/Observed(O) = 0.99; CI 0.92–1.06] ing the stopping age from 74 to 80 compared to the national and 563 LC deaths (E/O = 0.94 CI 0.87–1.03) in the lung screening trial (NLST) entry criterion. This decision screening arm that has an average compliance rate of was made partly with model-based analyses from cancer 87.9% over four annual screening rounds. We predict that intervention and surveillance modeling network (CISNET), perfect compliance to the USPSTF http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cancer Causes & Control Springer Journals

Evaluating the impact of varied compliance to lung cancer screening recommendations using a microsimulation model

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Publisher
Springer International Publishing
Copyright
Copyright © 2017 by Springer International Publishing AG
Subject
Biomedicine; Cancer Research; Biomedicine, general; Oncology; Public Health; Epidemiology; Hematology
ISSN
0957-5243
eISSN
1573-7225
D.O.I.
10.1007/s10552-017-0907-x
Publisher site
See Article on Publisher Site

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