Reactions 1704, p159 - 2 Jun 2018
Amblyopia: case report
A 70-year-old man developed amblyopia following
treatment with ethambutol [route, dosage, duration of
treatment to time to reaction onset not stated].
The man was diagnosed with tuberculosis on
24 September 2015 and started receiving treatment with
isoniazid, rifampicin, pyrazinamide and ethambutol. Before
the initiation of the treatment, he reported of left eye blurred
vision, and his right eye (cataract) had vision of 20/70 and
normal colour discrimination. He reported of blurred vision
deterioration on 5 January 2016. On 7 January 2016, he was
diagnosed with degenerative glaucoma. On 18 January 2016,
he underwent operation for cataract in his right eye. However,
he reported abnormal colour discrimination on
26 January 2016.
The man’s tuberculosis treatment was discontinued on
30 January 2016 [outcome not stated].
Author comment: "[Ethambutol] related blurred vision is
most likely to be confused with degenerative diseases in the
Ji Y-J, et al. Experience sharing of amblyopia caused by EMB drugs in regional
hospitals. International Journal of Antimicrobial Agents 50 (Suppl. 2): S252-S253,
Nov 2017 [abstract] - Taiwan
Reactions 2 Jun 2018 No. 17040114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved