Keywords Ionic liquid Antitubercular activity Cytotoxicity Rhodanine and Knoevenagel condensation Introduction Almost 9 million new cases of human tuberculosis (TB) are diagnosed and 1.5 million deaths are reported worldwide . Mycobacterium tuberculosis (MTB)is among the most challenging bacterial infections, requiring daily combination therapy of up to 4 drugs for at least 6 months to treat uncomplicated drug-sensitive infections . Nowadays, synergy with HIV and the appearance of MTB strains, which are multi-drug resistant or hyper-virulent, poses further threats [3–5]. Thus, the discovery of novel anti-TB drug targets is of increasing importance in combating this disease. In addition, M. bovis BCG vaccination is also among the most commonly administered vaccines worldwide . It is usually the ﬁrst vaccine administered to newborns in developing countries and is a part of the expanded programme of immunization of the World Health Organization WHO . Rhodanine (2-thioxothiazolid-4-one) and their analogues have been known as privileged structures in pharmacological research which display a broad spectrum of biological activities . In particular, 5-arylidene rhodanines display antifungal  and antibacterial properties [10, 11], are DNA polymerase k inhibitors [12, 13], and anti-inﬂammatory [14, 15], while ZTB24, ZTB28R and ZTB29R are antitubercular agents [16, 17].
Research on Chemical Intermediates – Springer Journals
Published: Feb 29, 2016
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