Et3N catalyzed cascade reaction of Meldrum’s acid with ortho-hydroxyaryl aldehydes for the synthesis of coumarin-3-carboxylic acids under solvent-less condition

Et3N catalyzed cascade reaction of Meldrum’s acid with ortho-hydroxyaryl aldehydes for the... Keywords Coumarin-3-carboxylic acids  Triethylamine  Water Environmentally friendly Electronic supplementary material The online version of this article (doi:10.1007/s11164-016-2517-8) contains supplementary material, which is available to authorized users. & Cheng-Wei Lu ¨ chengweilv@126.com School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, People’s Republic of China 123 7058 W.-Y. Pan et al. Introduction Over the past few decades, the synthesis of coumarin and its derivatives has attracted considerable attention from organic and medicinal chemists due to coumarin (2-oxo-2H-1-benzopyran) heterocyclic moiety being a ‘‘privileged’’ structural motif both in numerous natural products and synthetic organic compounds of potential pharmacological activities [1–6]. They are also key components for flavoring of a diverse set of foods [7–11]. Coumarin-3-carboxylic acids are key precursors for the synthesis of coumarins and also act as vital building blocks of various natural and semisynthetic pharmacological agents [12]. Because of these advantages of coumarin-3-carboxylic acids, the search for new and more convenient methods to accomplish their synthesis is desirable and significant [13]. Several routes have been reported in the literature for the synthesis of coumarin-3- carboxylic acid derivatives [14–16]. The Knoevenagel condensation of ortho- hydroxyarylaldehydes with Meldrum’s acid is one of the simplest methiods because of several http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Et3N catalyzed cascade reaction of Meldrum’s acid with ortho-hydroxyaryl aldehydes for the synthesis of coumarin-3-carboxylic acids under solvent-less condition

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Publisher
Springer Journals
Copyright
Copyright © 2016 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-016-2517-8
Publisher site
See Article on Publisher Site

Abstract

Keywords Coumarin-3-carboxylic acids  Triethylamine  Water Environmentally friendly Electronic supplementary material The online version of this article (doi:10.1007/s11164-016-2517-8) contains supplementary material, which is available to authorized users. & Cheng-Wei Lu ¨ chengweilv@126.com School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, People’s Republic of China 123 7058 W.-Y. Pan et al. Introduction Over the past few decades, the synthesis of coumarin and its derivatives has attracted considerable attention from organic and medicinal chemists due to coumarin (2-oxo-2H-1-benzopyran) heterocyclic moiety being a ‘‘privileged’’ structural motif both in numerous natural products and synthetic organic compounds of potential pharmacological activities [1–6]. They are also key components for flavoring of a diverse set of foods [7–11]. Coumarin-3-carboxylic acids are key precursors for the synthesis of coumarins and also act as vital building blocks of various natural and semisynthetic pharmacological agents [12]. Because of these advantages of coumarin-3-carboxylic acids, the search for new and more convenient methods to accomplish their synthesis is desirable and significant [13]. Several routes have been reported in the literature for the synthesis of coumarin-3- carboxylic acid derivatives [14–16]. The Knoevenagel condensation of ortho- hydroxyarylaldehydes with Meldrum’s acid is one of the simplest methiods because of several

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Mar 28, 2016

References

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