Et3N catalyzed cascade reaction of Meldrum’s acid with ortho-hydroxyaryl aldehydes for the synthesis of coumarin-3-carboxylic acids under solvent-less condition

Et3N catalyzed cascade reaction of Meldrum’s acid with ortho-hydroxyaryl aldehydes for the... Keywords Coumarin-3-carboxylic acids  Triethylamine  Water Environmentally friendly Electronic supplementary material The online version of this article (doi:10.1007/s11164-016-2517-8) contains supplementary material, which is available to authorized users. & Cheng-Wei Lu ¨ chengweilv@126.com School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, People’s Republic of China 123 7058 W.-Y. Pan et al. Introduction Over the past few decades, the synthesis of coumarin and its derivatives has attracted considerable attention from organic and medicinal chemists due to coumarin (2-oxo-2H-1-benzopyran) heterocyclic moiety being a ‘‘privileged’’ structural motif both in numerous natural products and synthetic organic compounds of potential pharmacological activities [1–6]. They are also key components for flavoring of a diverse set of foods [7–11]. Coumarin-3-carboxylic acids are key precursors for the synthesis of coumarins and also act as vital building blocks of various natural and semisynthetic pharmacological agents [12]. Because of these advantages of coumarin-3-carboxylic acids, the search for new and more convenient methods to accomplish their synthesis is desirable and significant [13]. Several routes have been reported in the literature for the synthesis of coumarin-3- carboxylic acid derivatives [14–16]. The Knoevenagel condensation of ortho- hydroxyarylaldehydes with Meldrum’s acid is one of the simplest methiods because of several http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Et3N catalyzed cascade reaction of Meldrum’s acid with ortho-hydroxyaryl aldehydes for the synthesis of coumarin-3-carboxylic acids under solvent-less condition

Loading next page...
 
/lp/springer_journal/et3n-catalyzed-cascade-reaction-of-meldrum-s-acid-with-ortho-chh7x1J7F4
Publisher
Springer Netherlands
Copyright
Copyright © 2016 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-016-2517-8
Publisher site
See Article on Publisher Site

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial