Keywords Coumarin-3-carboxylic acids Triethylamine Water Environmentally friendly Electronic supplementary material The online version of this article (doi:10.1007/s11164-016-2517-8) contains supplementary material, which is available to authorized users. & Cheng-Wei Lu ¨ email@example.com School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, People’s Republic of China 123 7058 W.-Y. Pan et al. Introduction Over the past few decades, the synthesis of coumarin and its derivatives has attracted considerable attention from organic and medicinal chemists due to coumarin (2-oxo-2H-1-benzopyran) heterocyclic moiety being a ‘‘privileged’’ structural motif both in numerous natural products and synthetic organic compounds of potential pharmacological activities [1–6]. They are also key components for ﬂavoring of a diverse set of foods [7–11]. Coumarin-3-carboxylic acids are key precursors for the synthesis of coumarins and also act as vital building blocks of various natural and semisynthetic pharmacological agents . Because of these advantages of coumarin-3-carboxylic acids, the search for new and more convenient methods to accomplish their synthesis is desirable and signiﬁcant . Several routes have been reported in the literature for the synthesis of coumarin-3- carboxylic acid derivatives [14–16]. The Knoevenagel condensation of ortho- hydroxyarylaldehydes with Meldrum’s acid is one of the simplest methiods because of several
Research on Chemical Intermediates – Springer Journals
Published: Mar 28, 2016
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