Estimation of Allele Frequencies in Indigenous Populations of Siberia Based on Pedigree Data

Estimation of Allele Frequencies in Indigenous Populations of Siberia Based on Pedigree Data Procedure is described to estimate allele frequencies in indigenous populations of Siberia using phenotype data not only for “pure-blood” representatives of the ethnic groups examined, but also for the descendants of mixed marriages. Implementation of the method requires reconstruction of the pedigree structure for the sample examined. Inclusion of the data on descendants of mixed marriages into the analysis increases the sample information content and decreases variance of the estimates obtained. The advantages of the method are illustrated using an example of Tundra Nentsy, for whom it was shown that variance of estimates at the analysis of the blood groups allele frequencies can be diminished approximately by a factor of 1.5. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Estimation of Allele Frequencies in Indigenous Populations of Siberia Based on Pedigree Data

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Publisher
Kluwer Academic Publishers-Plenum Publishers
Copyright
Copyright © 2001 by MAIK “Nauka/Interperiodica”
Subject
Biomedicine; Human Genetics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1023/A:1012513226719
Publisher site
See Article on Publisher Site

Abstract

Procedure is described to estimate allele frequencies in indigenous populations of Siberia using phenotype data not only for “pure-blood” representatives of the ethnic groups examined, but also for the descendants of mixed marriages. Implementation of the method requires reconstruction of the pedigree structure for the sample examined. Inclusion of the data on descendants of mixed marriages into the analysis increases the sample information content and decreases variance of the estimates obtained. The advantages of the method are illustrated using an example of Tundra Nentsy, for whom it was shown that variance of estimates at the analysis of the blood groups allele frequencies can be diminished approximately by a factor of 1.5.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Oct 16, 2004

References

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