Short Communication Incorporating Mouse Genome Mammalian Genome 12, 938–941 (2001). © Springer-Verlag New York Inc. 2001 DOI: 10.1007/s00335-001-2087-x Establishing an ENU mutagenesis screen for the piebald region of mouse Chromosome 14 Aaron Hagge-Greenberg, Peter Snow, Timothy P. O’Brien The Jackson Laboratory, Bar Harbor, Maine 04609, USA Received: 25 May 2001 / Accepted: 7 August 2001 Genetic screens represent a fundamental approach for recovering in an effort to identify genes that are required for development. mutations that are invaluable for understanding biology and dis- Complementation mapping has been used to define discrete chro- ease. In several model systems, chemical mutagens such as ethyl- mosomal intervals associated with defects in gastrulation and me- nitrosourea (ENU) or ethylmethanesulfonate (EMS) have been soderm development, central nervous system development, and used to build large collections of genetic variants by using pheno- skeletal patterning and craniofacial morphogenesis (O’Brien et al. type-driven screens. In the mouse, the discovery that ENU can act 1996; Roix et al. 2001). as a high-efficiency germline mutagen has permitted the applica- As one approach to validate candidate genes for the previously tion of chemical mutagenesis screens comparable to those used in characterized deletion allele phenotypes and to assign function to yeast,
Mammalian Genome – Springer Journals
Published: Feb 19, 2014
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