Escalated cocaine “binges” in rats: enduring effects of social defeat stress or intra-VTA CRF

Escalated cocaine “binges” in rats: enduring effects of social defeat stress or intra-VTA CRF Rationale Exposure to intermittent social defeat stress elicits tently alters cocaine valuation and intensifies binge-like drug corticotropin releasing factor (CRF) release into the VTA and intake in a CRF-R1-dependent manner. Conversely, the per- induces long-term modulation of mesocorticolimbic dopa- sistent pattern of cocaine bingeing induced by social defeat mine activity in rats. These adaptations are associated with stress may suggest impaired inhibitory control, independent of an intense cocaine-taking phenotype, which is prevented by reward valuation. CRF receptor antagonists. Objective The present studies examine whether infusion of Keywords Social defeat stress Corticotropin releasing factor . . CRF into the VTA is sufficient to escalate cocaine-taking (CRF) Ventral tegmental area (VTA) Behavioral . . behavior, in the absence of social defeat experience. economics Cocaine Self-administration Additionally, we aimed to characterize changes in cocaine valuation that may promote binge-like cocaine intake. Methods Male Long-Evans rats were microinjected into the Introduction VTA with CRF (50 or 500 ng/side), vehicle, or subjected to social defeat stress, intermittently over 10 days. Animals were Repeated exposure to stressful events is associated with an then trained to self-administer IV cocaine (FR5). Economic increased vulnerability to drug abuse (Sinha 2001;Goeders demand for cocaine was evaluated using a within-session Psychopharmacology Springer Journals

Escalated cocaine “binges” in rats: enduring effects of social defeat stress or intra-VTA CRF

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Springer Berlin Heidelberg
Copyright © 2017 by Springer-Verlag GmbH Germany
Biomedicine; Neurosciences; Pharmacology/Toxicology; Psychiatry
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