Erlotinib

Erlotinib Reactions 1704, p152 - 2 Jun 2018 Folliculitis decalvans and bacterial superinfection: case report A 66-year-old woman developed folliculitis decalvans and bacterial superinfection during treatment with erlotinib for metastatic pulmonary adenocarcinoma. Subsequently, she died. The woman, who had been diagnosed with metastatic pulmonary adenocarcinoma, started receiving erlotinib 150 mg/day [route not stated]. She presented with grade I papulopustular rash, which progressed to grade II rash during the next three weeks. The woman was treated with topical corticosteroids along with doxycycline, but response was poor. Her erlotinib dose was decreased to 100 mg/day, which controlled the papulopustular lesions. Six months later, she had a follow-up visit at dermatologist for her crusted scalp lesions. A physical examination showed generalised swelling all over the scalp over a confluent and malodorous pustular base. She was diagnosed with bacterial superinfection secondary to erlotinib. The sample of the exudate was taken for culture and doxycycline was initiated. In the culture, Methicillin-sensitive Staphylococcus aureus was isolated. Her treatment was planned according to the antibiogram. But, her condition deteriorated over the following days, with increased hair loss, leaving deepithelialised alopecic plaques with a scar-like appearance alternating with purulent and macerated areas. A diagnosis of folliculitis decalvans due to bacterial superinfection secondary to erlotinib was made. A week later, she died of acute pulmonary thromboembolism. Author comment: "In conclusion, we present a case of bacterial superinfection associated with erlotinib that manifested as folliculitis decalvans, a complication that has received little attention in the literature". Sahuquillo-Torralba A, et al. Folliculitis Decalvans Caused by Bacterial Superinfection Secondary to Erlotinib. Actas Dermo-Sifiliograficas 109: 363-364, No. 4, May 2018. Available from: URL: http://doi.org/10.1016/ j.adengl.2018.03.007 - Spain 803323229 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Erlotinib

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46795-1
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p152 - 2 Jun 2018 Folliculitis decalvans and bacterial superinfection: case report A 66-year-old woman developed folliculitis decalvans and bacterial superinfection during treatment with erlotinib for metastatic pulmonary adenocarcinoma. Subsequently, she died. The woman, who had been diagnosed with metastatic pulmonary adenocarcinoma, started receiving erlotinib 150 mg/day [route not stated]. She presented with grade I papulopustular rash, which progressed to grade II rash during the next three weeks. The woman was treated with topical corticosteroids along with doxycycline, but response was poor. Her erlotinib dose was decreased to 100 mg/day, which controlled the papulopustular lesions. Six months later, she had a follow-up visit at dermatologist for her crusted scalp lesions. A physical examination showed generalised swelling all over the scalp over a confluent and malodorous pustular base. She was diagnosed with bacterial superinfection secondary to erlotinib. The sample of the exudate was taken for culture and doxycycline was initiated. In the culture, Methicillin-sensitive Staphylococcus aureus was isolated. Her treatment was planned according to the antibiogram. But, her condition deteriorated over the following days, with increased hair loss, leaving deepithelialised alopecic plaques with a scar-like appearance alternating with purulent and macerated areas. A diagnosis of folliculitis decalvans due to bacterial superinfection secondary to erlotinib was made. A week later, she died of acute pulmonary thromboembolism. Author comment: "In conclusion, we present a case of bacterial superinfection associated with erlotinib that manifested as folliculitis decalvans, a complication that has received little attention in the literature". Sahuquillo-Torralba A, et al. Folliculitis Decalvans Caused by Bacterial Superinfection Secondary to Erlotinib. Actas Dermo-Sifiliograficas 109: 363-364, No. 4, May 2018. Available from: URL: http://doi.org/10.1016/ j.adengl.2018.03.007 - Spain 803323229 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

References

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