Ergometrine Reactions 1680, p129 - 2 Dec 2017 Sick sinus syndrome, complete atrioventricular block and junctional escape rhythm: case report A 38-year-old woman developed sick sinus syndrome, complete atrioventricular block and junctional escape rhythm during treatment with ergometrine [ergonovine]. The woman, who had primary infertility, received in vitro fertilisation. A routine transvaginal ultrasonography at follow- up revealed swelling in the right adnexa without intrauterine embryo. The right adnexa mass was regarded as a hydrosalpinx after an exploratory laparoscopy. Following laparoscopic surgery, vaginal bleeding occurred. Consequently, she received therapy with oral ergometrine 0.2mg thrice a day to facilitate uterine contraction, under the impression of complete abortion. After the fourth dose, she developed mild chest tightness and general weakness. However, a complete AV block presenting with type 1 and type 2 second-degree sino-atrial exit block and junctional escape rhythm were revealed by an ECG. Ergometrine was suspected to be the cause of her transient sick sinus syndrome and complete AV block with junctional space rhythm. The woman received conservative treatment. Bed rest was suggested to her. Ergometrine was withdrawn. Her sinus rhythm recovered one day after ergometrine discontinuation. She remained asymptomatic after the recovery of sinus rhythm. Author comment: "The Naranjo adverse drug reaction (ADR) causality score was 5, which represented probable ADR of ergonovine in this case." Wang HT, et al. Transient sick sinus syndrome with complete atrioventricular block associated with ergonovine intake: A case report. Medicine 96: e8559, No. 44, Nov 2017. Available from: URL: MD.0000000000008559 - Taiwan 803283905 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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