Epirubicin/cyclophosphamide

Epirubicin/cyclophosphamide Reactions 1680, p127 - 2 Dec 2017 Periaortitis: case report A 55-year-old woman developed periaortitis following treatment with epirubicin and cyclophosphamide. The woman was diagnosed with T2N1M1 stage IV breast carcinoma. She received chemotherapy with IV epirubicin 2 2 90 mg/m on day 1 and IV cyclophosphamide 600 mg/m on day 1. Her other medications included dexamethasone, aprepitant and palonosetron. She developed a high grade fever and stomatitis on day 11 after the initiation of the chemotherapy. Her WBC count was normal, but a severe inflammatory reaction was revealed by the laboratory data. The woman received unspecified antibiotic treatment on admission. During the clinical course, granulocytosis was noted. On day 14 of the initiation of chemotherapy, a CT scan did not reveal any findings relating to the fever’s origin. The elevated CRP values and fever were persistent. The WBC count rose to 14500/µL on day 20, but her condition was stable. She had complaints of back pain on day 25. A repeat CT scan revealed thickening of the rind surrounding the descending aorta along with bilateral pleural effusions. These findings were indicative of acute periaortitis. The examinations relating to connective tissue disease and vasculitis were normal. Antibiotic therapy was discontinued on day 20. Her fever resolved. Her WBC count also decreased. On day 33 after the initiation of chemotherapy, she was discharged. She then received chemotherapy with docetaxel, pertuzumab and trastuzumab. No inflammatory reactions were observed. On day 90, CT scan was performed, which revealed resolution of the thickened rind of the descending aorta. No aneurysmic changes were observed. Author comment: "We herein report a case of periaortitis with a high-grade fever during chemotherapy with epirubicin and cyclophosphamide for breast cancer." Inoue M, et al. Periaortitis induced by epirubicin and cyclophosphamide for a patient with advanced breast cancer. International Cancer Conference Journal 6: 180-183, No. 4, Oct 2017. Available from: URL: http://doi.org/10.1007/ s13691-017-0302-1 - Japan 803285058 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Epirubicin/cyclophosphamide

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Publisher
Springer International Publishing
Copyright
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-017-39058-6
Publisher site
See Article on Publisher Site

Abstract

Reactions 1680, p127 - 2 Dec 2017 Periaortitis: case report A 55-year-old woman developed periaortitis following treatment with epirubicin and cyclophosphamide. The woman was diagnosed with T2N1M1 stage IV breast carcinoma. She received chemotherapy with IV epirubicin 2 2 90 mg/m on day 1 and IV cyclophosphamide 600 mg/m on day 1. Her other medications included dexamethasone, aprepitant and palonosetron. She developed a high grade fever and stomatitis on day 11 after the initiation of the chemotherapy. Her WBC count was normal, but a severe inflammatory reaction was revealed by the laboratory data. The woman received unspecified antibiotic treatment on admission. During the clinical course, granulocytosis was noted. On day 14 of the initiation of chemotherapy, a CT scan did not reveal any findings relating to the fever’s origin. The elevated CRP values and fever were persistent. The WBC count rose to 14500/µL on day 20, but her condition was stable. She had complaints of back pain on day 25. A repeat CT scan revealed thickening of the rind surrounding the descending aorta along with bilateral pleural effusions. These findings were indicative of acute periaortitis. The examinations relating to connective tissue disease and vasculitis were normal. Antibiotic therapy was discontinued on day 20. Her fever resolved. Her WBC count also decreased. On day 33 after the initiation of chemotherapy, she was discharged. She then received chemotherapy with docetaxel, pertuzumab and trastuzumab. No inflammatory reactions were observed. On day 90, CT scan was performed, which revealed resolution of the thickened rind of the descending aorta. No aneurysmic changes were observed. Author comment: "We herein report a case of periaortitis with a high-grade fever during chemotherapy with epirubicin and cyclophosphamide for breast cancer." Inoue M, et al. Periaortitis induced by epirubicin and cyclophosphamide for a patient with advanced breast cancer. International Cancer Conference Journal 6: 180-183, No. 4, Oct 2017. Available from: URL: http://doi.org/10.1007/ s13691-017-0302-1 - Japan 803285058 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680

Journal

Reactions WeeklySpringer Journals

Published: Dec 2, 2017

References

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