Epigenetics of Childhood Obesity

Epigenetics of Childhood Obesity Curr Pediatr Rep (2017) 5:111–117 DOI 10.1007/s40124-017-0133-8 OBESITY (S ARMSTRONG AND A PATEL, SECTION EDITORS) 1 1,2 Kara Wegermann & Cynthia A. Moylan Published online: 30 June 2017 Springer Science + Business Media New York 2017 . . . Abstract Keywords Epigenetics Obesity Methylation MicroRNA Purpose of Review We sought to describe how epigenetics, the study of potentially heritable changes in gene expression that do not involve changes in the underlying DNA sequence, Introduction has promise in the development of effective preventive inter- ventions for childhood obesity. The Promise of Epigenetics Recent Findings Three main mechanisms cause epigenetic changes: DNA methylation, histone and chromatin modifica- The childhood obesity epidemic’s scale and public health con- tion, and post-translational regulation, including that by sequences have intensified the search for effective prevention microRNAs (miRNAs). These mechanisms may be altered strategies. One area of great promise, although still in its in- by a variety of exposures, and evidence suggests they act at fancy, is epigenetics. Epigenetics is the study of potentially multiple time points prior to conception, during pregnancy, heritable changes in gene expression that do not involve and during infancy and childhood. Epigenetic changes, partic- changes in the underlying DNA sequence. Thus, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Pediatrics Reports Springer Journals

Epigenetics of Childhood Obesity

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Publisher
Springer US
Copyright
Copyright © 2017 by Springer Science + Business Media New York
Subject
Medicine & Public Health; Pediatrics
eISSN
2167-4841
D.O.I.
10.1007/s40124-017-0133-8
Publisher site
See Article on Publisher Site

Abstract

Curr Pediatr Rep (2017) 5:111–117 DOI 10.1007/s40124-017-0133-8 OBESITY (S ARMSTRONG AND A PATEL, SECTION EDITORS) 1 1,2 Kara Wegermann & Cynthia A. Moylan Published online: 30 June 2017 Springer Science + Business Media New York 2017 . . . Abstract Keywords Epigenetics Obesity Methylation MicroRNA Purpose of Review We sought to describe how epigenetics, the study of potentially heritable changes in gene expression that do not involve changes in the underlying DNA sequence, Introduction has promise in the development of effective preventive inter- ventions for childhood obesity. The Promise of Epigenetics Recent Findings Three main mechanisms cause epigenetic changes: DNA methylation, histone and chromatin modifica- The childhood obesity epidemic’s scale and public health con- tion, and post-translational regulation, including that by sequences have intensified the search for effective prevention microRNAs (miRNAs). These mechanisms may be altered strategies. One area of great promise, although still in its in- by a variety of exposures, and evidence suggests they act at fancy, is epigenetics. Epigenetics is the study of potentially multiple time points prior to conception, during pregnancy, heritable changes in gene expression that do not involve and during infancy and childhood. Epigenetic changes, partic- changes in the underlying DNA sequence. Thus,

Journal

Current Pediatrics ReportsSpringer Journals

Published: Jun 30, 2017

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