Biochem Genet https://doi.org/10.1007/s10528-018-9863-8 REVIEW Epigenetic Modifications Linked to T2D, the Heritability Gap, and Potential Therapeutic Targets 1,2 3 4 1,5 Monica Szabó · Beáta Máté · Katalin Csép · Theodora Benedek Received: 20 March 2017 / Accepted: 16 May 2018 © Springer Science+Business Media, LLC, part of Springer Nature 2018 Abstract With the pandemic of type 2 diabetes (T2D), there is an ever-increasing need to fully understand the underlying mechanisms of the disease. Type 2 diabe- tes shows a high heritability risk (25–80%); however, genes account only for 10% of this risk. From all the risk factors for diabetes, epigenetic mechanisms have the highest statistical scoring in explaining the disease. A multitude of organ-specific epigenomic changes have been linked to type 2 diabetes. Nutritional influences, mainly in the early life, physical activity level, environmental toxins act as epige- netic factors and the recognized epigenetic changes can represent a therapeutical target, new drugs being currently in development for this application. Our current review focuses on the most common epigenetic modifications linked to type 2 dia - betes or insulin resistance, the potentially emerging epigenetic-related interventions and pharmacoepigenetic knowledge. Keywords Epigenetics of type 2 diabetes · Nutritional epigenetic effects · DNA methylation · Histone modification, non-coding RNAs · Pharamacoepigenetic * Monica Szabó
Biochemical Genetics – Springer Journals
Published: Jun 5, 2018
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