Epigenetic epidemiology of age-related diseases

Epigenetic epidemiology of age-related diseases Many studies have shown that organism is mostly sensitive to different influences in pre- and postnatal periods of ontogenesis. During the critical periods of development, these influences induce changes in the organism that relate to ontogenetic plasticity and lead to permanent changes in structure and function of different organs and systems of the organism. It is suggested that the main molecular mechanisms of so-called “ontogenetic programming” are based on changes that occur on the epigenetic level, including changes in the genetic expression not connected with modifications of DNA structure. The present review deals with experimental and epidemiologic evidences of the role of epigenetic processes in aging and determination of susceptibility to some age-related diseases, such as cancer, cardiovascular and neurodegenerative diseases, and insulin-independent diabetes. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Developmental Biology Springer Journals

Epigenetic epidemiology of age-related diseases

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Publisher
Springer Journals
Copyright
Copyright © 2011 by Pleiades Publishing, Ltd.
Subject
Life Sciences; Animal Anatomy / Morphology / Histology; Developmental Biology
ISSN
1062-3604
eISSN
1608-3326
D.O.I.
10.1134/S1062360411010127
Publisher site
See Article on Publisher Site

Abstract

Many studies have shown that organism is mostly sensitive to different influences in pre- and postnatal periods of ontogenesis. During the critical periods of development, these influences induce changes in the organism that relate to ontogenetic plasticity and lead to permanent changes in structure and function of different organs and systems of the organism. It is suggested that the main molecular mechanisms of so-called “ontogenetic programming” are based on changes that occur on the epigenetic level, including changes in the genetic expression not connected with modifications of DNA structure. The present review deals with experimental and epidemiologic evidences of the role of epigenetic processes in aging and determination of susceptibility to some age-related diseases, such as cancer, cardiovascular and neurodegenerative diseases, and insulin-independent diabetes.

Journal

Russian Journal of Developmental BiologySpringer Journals

Published: Feb 13, 2011

References

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