Epigenetic effect of the rad201(G1) mutation in a system with mobilization of nonautonomous P elements in Drosophila

Epigenetic effect of the rad201(G1) mutation in a system with mobilization of nonautonomous P... The effect on P-element activity in somatic cells was studied for a repair mutation localized in the Drosophila genome in the region of the rad201 and Rad51C overlapping genes. When one of the parents carried nonautonomous P elements and the rad201 mutation and the other carried a P-transposase source, a high dominant pupal lethality was observed in the progeny heterozygous for the mutant allele and their sibs homozygous for the rad201 + wild-type allele. The sib response was due to the epigenetic effect of the rad201 mutation and was maintained through at least two generations. The specifics of the epigenetic effect are discussed in terms of its possible association with P transpositions and mitotic crossing over events determined by P transposase. Based on the results of genetic and genomic DNA analyses of the rad201 mutant, it was assumed that the phenomenon in question was determined by several genetic factors. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Epigenetic effect of the rad201(G1) mutation in a system with mobilization of nonautonomous P elements in Drosophila

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Publisher
SP MAIK Nauka/Interperiodica
Copyright
Copyright © 2008 by Pleiades Publishing, Ltd.
Subject
Biomedicine; Microbial Genetics and Genomics; Animal Genetics and Genomics; Human Genetics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1134/S1022795408030083
Publisher site
See Article on Publisher Site

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