EPC-K1 protects neuronal cells from peroxynitrite-mediated oxidative damage

EPC-K1 protects neuronal cells from peroxynitrite-mediated oxidative damage Protective effects of EPC-K1 (L-ascorbic acid 2-[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyldecyl)-2H-1-benzopyran-6-yl-hydrogen phosphate] potassium salt, a difunctional derivative of vitamin C and vitamin E) on neuronal cell damage mediated by peroxynitrite were studied. Primary cultures of cerebellar granule cells were exposed to peroxynitrite by treatment with 3-morpholinosydnonimine-N-ethylcarbamide (SIN-1), which generated nitric oxide and superoxide anion simultaneously upon decomposition. The results showed that SIN-1 treatment triggered time-dependent cell death, which was accompanied by the decrease in the cellular GSH level, the increase in the lipid peroxidation level, and the alteration of cell membrane biophysical characteristics. EPC-K1 showed only moderate scavenging effect on peroxynitrite, but could effectively protect neuronal cells from oxidative damage mediated by peroxynitrite. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

EPC-K1 protects neuronal cells from peroxynitrite-mediated oxidative damage

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Springer Netherlands
Copyright © 2000 by Springer
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
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