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J Membrane Biol (2012) 245:759–760 DOI 10.1007/s00232-012-9439-1 LETTE R T O T HE EDI T OR • • David D. Busath Dixon J. Woodbury Adam Frost Received: 16 April 2012 / Accepted: 30 April 2012 / Published online: 1 June 2012 Springer Science+Business Media, LLC 2012 To the Editor, Exosis Endocytosis and exocytosis are named for the fact that vesicle action (-osis) is movement into (endo-) or out of Cell (exo-) the cell (-cyt-). Vesicle budding and fusion of Endosis Exocytosis extracellular vesicles to cells are also commonplace pro- cesses in biology (Mause and Weber 2010; Nabhan et al. 2012) but lack formal names. For instance, budding occurs Extracellular Endocytosis from cells infected by enveloped viruses or undergoing apoptosis and from apocrine glands and megakaryocytes. Fig. 1 Proposed terms for budding (exosis) and fusion (endosis) The products of budding are sometimes referred to as ‘‘exosomes’’ (Keller et al. 2006). Fusion of external vesi- Alternatively, names could be based on vesicles moving cles to a cell is exemplified by HIV fusion to natural killer away from (ab-) or toward (ad-) the plasmalemma or as cells. Budding and subsequent fusion of exosomal vesicles external instead of internal processes. However, each of
The Journal of Membrane Biology – Springer Journals
Published: Jun 1, 2012
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