Emerging Diagnostic and Therapeutic Strategies for Tauopathies

Emerging Diagnostic and Therapeutic Strategies for Tauopathies Purpose of Review Tauopathies represent a spectrum of incur- markers will aid in identifying tauopathies earlier and more able and progressive age-associated neurodegenerative dis- accurately which will aid in selection for new clinical trials eases that currently are diagnosed definitively only at autopsy. which focus on a variety of agents including immunotherapy Few clinical diagnoses, such as classic Richardson’ssyn- and gene silencing. drome of progressive supranuclear palsy, are specific for un- . . derlying tauopathy and no clinical syndrome is fully sensitive Keywords Tauopathy Progressive supranuclear palsy . . . to reliably identify all forms of clinically manifest tauopathy. Alzheimer’sdisease Immunotherapy Gene therapy Thus, a major unmet need for the development and implemen- Tau-PET tation of tau-targeted therapies is precise antemortem diagno- sis. This article reviews new and emerging diagnostic thera- pies for tauopathies including novel imaging techniques and Introduction biomarkers and also reviews recent tau therapeutics. Recent Findings Building evidence from animal and cell Tau is a highly soluble microtubule-associated protein which models suggests that prion-like misfolding and propagation modulates stability of axonal cytoskeleton and is encoded by of pathogenic tau proteins between brain cells are central to the MAPT gene on chromosome 17q21.3 consisting of 16 the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Neurology and Neuroscience Reports Springer Journals

Emerging Diagnostic and Therapeutic Strategies for Tauopathies

Loading next page...
Springer US
Copyright © 2017 by Springer Science+Business Media, LLC
Medicine & Public Health; Neurology; Neurosciences
Publisher site
See Article on Publisher Site

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial