Purpose of Review Tauopathies represent a spectrum of incur- markers will aid in identifying tauopathies earlier and more able and progressive age-associated neurodegenerative dis- accurately which will aid in selection for new clinical trials eases that currently are diagnosed definitively only at autopsy. which focus on a variety of agents including immunotherapy Few clinical diagnoses, such as classic Richardson’ssyn- and gene silencing. drome of progressive supranuclear palsy, are specific for un- . . derlying tauopathy and no clinical syndrome is fully sensitive Keywords Tauopathy Progressive supranuclear palsy . . . to reliably identify all forms of clinically manifest tauopathy. Alzheimer’sdisease Immunotherapy Gene therapy Thus, a major unmet need for the development and implemen- Tau-PET tation of tau-targeted therapies is precise antemortem diagno- sis. This article reviews new and emerging diagnostic thera- pies for tauopathies including novel imaging techniques and Introduction biomarkers and also reviews recent tau therapeutics. Recent Findings Building evidence from animal and cell Tau is a highly soluble microtubule-associated protein which models suggests that prion-like misfolding and propagation modulates stability of axonal cytoskeleton and is encoded by of pathogenic tau proteins between brain cells are central to the MAPT gene on chromosome 17q21.3 consisting of 16 the
Current Neurology and Neuroscience Reports – Springer Journals
Published: Aug 7, 2017
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