Electroporation-Based Technologies and Treatments

Electroporation-Based Technologies and Treatments J Membrane Biol (2010) 236:1–2 DOI 10.1007/s00232-010-9287-9 EDITORIAL • • Damijan Miklavc ˇic ˇ Lluis M. Mir P. Thomas Vernier Published online: 24 July 2010 Springer Science+Business Media, LLC 2010 When a cell is exposed to a sufficiently large electric field, countries, is routinely employed in more than 60 cancer even for a very short time, its plasma membrane is changed treatment centers and is being further developed for treat- so that molecules that normally cross the membrane only in ing more deep-seated tumors (Miklavcic et al. 2010). minute amounts can more readily pass through the barrier. Electroporation can be used in all kinds of isolated cells This phenomenon was first described by Neumann and as well as in tissues. The electric field to which one exposes Rosenheck (1972) in this journal. A decade later gene the target cell has to be of sufficient strength and the transfer was achieved by means of electroporation (Neu- exposure of sufficient duration. The magnitude of the mann et al. 1982). This technique is now widely used in electric field to be used depends on cell type, size, orien- laboratories around the world and is gaining even more tation and density; pulse duration; http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Membrane Biology Springer Journals

Electroporation-Based Technologies and Treatments

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Publisher
Springer-Verlag
Copyright
Copyright © 2010 by Springer Science+Business Media, LLC
Subject
Life Sciences; Human Physiology ; Biochemistry, general
ISSN
0022-2631
eISSN
1432-1424
D.O.I.
10.1007/s00232-010-9287-9
Publisher site
See Article on Publisher Site

Abstract

J Membrane Biol (2010) 236:1–2 DOI 10.1007/s00232-010-9287-9 EDITORIAL • • Damijan Miklavc ˇic ˇ Lluis M. Mir P. Thomas Vernier Published online: 24 July 2010 Springer Science+Business Media, LLC 2010 When a cell is exposed to a sufficiently large electric field, countries, is routinely employed in more than 60 cancer even for a very short time, its plasma membrane is changed treatment centers and is being further developed for treat- so that molecules that normally cross the membrane only in ing more deep-seated tumors (Miklavcic et al. 2010). minute amounts can more readily pass through the barrier. Electroporation can be used in all kinds of isolated cells This phenomenon was first described by Neumann and as well as in tissues. The electric field to which one exposes Rosenheck (1972) in this journal. A decade later gene the target cell has to be of sufficient strength and the transfer was achieved by means of electroporation (Neu- exposure of sufficient duration. The magnitude of the mann et al. 1982). This technique is now widely used in electric field to be used depends on cell type, size, orien- laboratories around the world and is gaining even more tation and density; pulse duration;

Journal

The Journal of Membrane BiologySpringer Journals

Published: Jul 24, 2010

References

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