J Membrane Biol (2010) 236:1–2 DOI 10.1007/s00232-010-9287-9 EDITORIAL • • Damijan Miklavc ˇic ˇ Lluis M. Mir P. Thomas Vernier Published online: 24 July 2010 Springer Science+Business Media, LLC 2010 When a cell is exposed to a sufﬁciently large electric ﬁeld, countries, is routinely employed in more than 60 cancer even for a very short time, its plasma membrane is changed treatment centers and is being further developed for treat- so that molecules that normally cross the membrane only in ing more deep-seated tumors (Miklavcic et al. 2010). minute amounts can more readily pass through the barrier. Electroporation can be used in all kinds of isolated cells This phenomenon was ﬁrst described by Neumann and as well as in tissues. The electric ﬁeld to which one exposes Rosenheck (1972) in this journal. A decade later gene the target cell has to be of sufﬁcient strength and the transfer was achieved by means of electroporation (Neu- exposure of sufﬁcient duration. The magnitude of the mann et al. 1982). This technique is now widely used in electric ﬁeld to be used depends on cell type, size, orien- laboratories around the world and is gaining even more tation and density; pulse duration;
The Journal of Membrane Biology – Springer Journals
Published: Jul 24, 2010
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