Kcv, isolated from a Chlorella virus, is the smallest known K+ channel. When Kcv is expressed in Xenopus oocytes and exposed to 50 mM [K+]o, its open-state current-voltage relationship (I-V) has the shape of a “tilted S” between −200 and +120 mV. Details of this shape depend on the conditioning voltage (V c) immediately before an I-V recording. Unexpectedly, the I-V relationships, recorded in different [K+]o, do intersect. These characteristics are numerically described here by fits of a kinetic model to the experimental data. In this model, the V c sensitivity of I-V is mainly assigned to an affinity increase of external K+ association at more positive voltages. The general, tilted-S shape as well as the unexpected intersections of the I-V relationships are kinetically described by a decrease of the cord conductance by the electrochemical driving force for K+ in either direction, like in fast V-dependent blocking by competing ions.
The Journal of Membrane Biology – Springer Journals
Published: Jun 13, 2007
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