Electrogenic Properties of the Sodium Pump in a Dynamic Model of Membrane Transport

Electrogenic Properties of the Sodium Pump in a Dynamic Model of Membrane Transport The general purpose of this theoretical work is to contribute to understand the physiological role of the electrogenic properties of the sodium pump, by studying a dynamic model that integrates diverse processes of ionic and water transport across the plasma membrane. For this purpose, we employ a mathematical model that describes the rate of change of the intracellular concentrations of Na+, K+ and Cl−, of the cell volume, and of the plasma membrane potential (V m ). We consider the case of a nonexcitable, nonpolarized cell expressing the sodium pump; Na+, K+, Cl− and water channels, and cotransporters of KCl and NaCl in its plasma membrane. We particularly analyze here the conditions under which the physiological V m can be generated in a predominantly electrogenic fashion, as a result of the activity of the sodium pump. A major conclusion of this study is that, for the cell model considered, a low potassium permeability is not a sufficient condition for a predominantly electrogenic generation of the V m by the sodium pump. The presence of an electroneutral exchange of Na+ and K+ represents a necessary additional requirement. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Membrane Biology Springer Journals

Electrogenic Properties of the Sodium Pump in a Dynamic Model of Membrane Transport

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Publisher
Springer-Verlag
Copyright
Copyright © Inc. by 2000 Springer-Verlag New York
Subject
Life Sciences; Biochemistry, general; Human Physiology
ISSN
0022-2631
eISSN
1432-1424
D.O.I.
10.1007/s00232001074
Publisher site
See Article on Publisher Site

Abstract

The general purpose of this theoretical work is to contribute to understand the physiological role of the electrogenic properties of the sodium pump, by studying a dynamic model that integrates diverse processes of ionic and water transport across the plasma membrane. For this purpose, we employ a mathematical model that describes the rate of change of the intracellular concentrations of Na+, K+ and Cl−, of the cell volume, and of the plasma membrane potential (V m ). We consider the case of a nonexcitable, nonpolarized cell expressing the sodium pump; Na+, K+, Cl− and water channels, and cotransporters of KCl and NaCl in its plasma membrane. We particularly analyze here the conditions under which the physiological V m can be generated in a predominantly electrogenic fashion, as a result of the activity of the sodium pump. A major conclusion of this study is that, for the cell model considered, a low potassium permeability is not a sufficient condition for a predominantly electrogenic generation of the V m by the sodium pump. The presence of an electroneutral exchange of Na+ and K+ represents a necessary additional requirement.

Journal

The Journal of Membrane BiologySpringer Journals

Published: Jul 1, 2000

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