ISSN 0362-1197, Human Physiology, 2017, Vol. 43, No. 4, pp. 488–490. © Pleiades Publishing, Inc., 2017.
Original Russian Text © A.B. Mulik, N.O. Nazarov, Y.A. Shatyr, A.N. Doletskiy, 2017, published in Fiziologiya Cheloveka, 2017, Vol. 43, No. 4, pp. 150–152.
Electroencephalographic Dynamics of Individual Alpha Peak
Frequency During the Female Ovarian-Menstrual Cycle
A. B. Mulik
*, N. O. Nazarov
, Y. A. Shatyr
, and A. N. Doletskiy
Volgograd State University,Volgograd, Russia
Volgograd State Medical University, Volgograd, Russia
Received June 30, 2016
Abstract– Electroencephalographic brain dynamics during the menstrual, follicular, preovulatory, ovulatory,
luteal and premenstrual phases of the female ovarian-menstrual cycle were analyzed. All subjects were
divided into 3 groups according to individual alpha peak frequency and reaction to rhythmical photostimula-
tion. Data obtained confirm the necessity to carry out experimental and clinical psychophysiological studies
of women in the phases of the ovarian-menstrual cycle.
Keywords: ovarian-menstrual cycle, electroencephalography, functional condition, individual alpha fre-
In recent years there has been growing interest in
the study of individual α-rhythm frequency of electro-
encephalogram (IAF), which is the most stable bio-
electric indicator of efficient cognitive performance
and balanced emotional responses [1, 2]. However,
changes in IAF are challenging in different phases of
the ovarian-menstrual cycle (OMC). A number of
authors consider no changes within the frequency
range of a dominating α-rhythm compared with the
frequency range of θ-rhythm and δ-rhythm during the
OMC . At the same time it is evident from some
results that the IAF decreases in the follicular  and
the late luteal phases , on the one hand and on the
other hand, the IAF increases in the luteal phase [3,
6]. Lack of IAF dynamics in girls with hormone defi-
ciency and contraceptive intake is revealed in some
Owing to the fact that variability of EEG and
objective definition of the OMC phases are not taken
into account, conclusions are contradictive.
The aim of this research was to study frequency
of dominating α-rhythm of EEG at rest and in rhyth-
mic photostimulation within the frequency range of
α-rhythm depending on different phases of the OMC.
EEG was recorded according to six phases of the
(1) menstrual phase (MP). EEG was recorded on
the second or third day of the menstruation cycle;
(2) follicular phase (FP). EEG was recorded on the
second day after menstruation;
(3) pre-ovulatory phase (POP). EEG was recorded
in 4–6 days in respect to the previous measurement.
Daily detection of the LH levels in urine was per-
formed employing immunoassay, excluding individu-
als with anovulatory cycle;
(4) ovulatory phase (OP). EEG was recorded on
the day of the maximal LH concentration in urine at
(5) luteal phase (LP). EEG was recorded in 5 days
in respect to the previous measurement;
(6) premenstrual phase (PMP). EEG was recorded
in six days in respect to the previous measurement.
EEG was registered in each OMC phase in
20 female students aged 17–22 employing “Enceph-
alan-131-03” system. We used a sampling frequency of
250 Hz and a band-pass signal between 0.5–35 Hz.
The study was conducted in a darkened screened
room, in a sitting position with eyes closed. Occipital
electrodes were attached at Oz, and an ear electrode
was used as a reference electrode.
Rhythmical white-light photostimulation was held
within the range of 10 Hz for 15 s to estimate variability
of IAF in different phases of the OMC after the back-
ground EEG had been registered. This frequency of
sensory input initiates the most pronounced changes
in bioelectrical activity of the brain . Fragments
without artifacts lasting for 10 s were chosen to be ana-
lyzed. Peak frequency in the range of 8–13 Hz was
considered as IAF.
The article was translated by the authors.