Elastogenesis-related gene polymorphisms and the risk of pelvic organ prolapse development

Elastogenesis-related gene polymorphisms and the risk of pelvic organ prolapse development Pelvic organ prolapse (POP) represents a urologic and gynecological disease, the development of which is governed both by environmental and genetic factors. We describe the results of our association study of polymorphic variants of genes involved in the assembly of elastic fibrils, namely, the lysyl oxidase-like protein 1 (LOXL1) and fibulin-3 (FBLN3) genes. We revealed an association of the rs2304719-T allele and rs2165241(C)–rs2304719(T)–rs893821(T) haplotype of the LOXL1 gene with an increased risk of POP development, as well as a weak association with the disease of the rs3791660-C allele and the rs3791679(T)–rs1367228(A)–rs3791660(C)–rs2033316(A) haplotype of the FBLN3 gene. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Elastogenesis-related gene polymorphisms and the risk of pelvic organ prolapse development

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Publisher
Pleiades Publishing
Copyright
Copyright © 2015 by Pleiades Publishing, Inc.
Subject
Biomedicine; Human Genetics; Animal Genetics and Genomics; Microbial Genetics and Genomics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1134/S1022795415100087
Publisher site
See Article on Publisher Site

Abstract

Pelvic organ prolapse (POP) represents a urologic and gynecological disease, the development of which is governed both by environmental and genetic factors. We describe the results of our association study of polymorphic variants of genes involved in the assembly of elastic fibrils, namely, the lysyl oxidase-like protein 1 (LOXL1) and fibulin-3 (FBLN3) genes. We revealed an association of the rs2304719-T allele and rs2165241(C)–rs2304719(T)–rs893821(T) haplotype of the LOXL1 gene with an increased risk of POP development, as well as a weak association with the disease of the rs3791660-C allele and the rs3791679(T)–rs1367228(A)–rs3791660(C)–rs2033316(A) haplotype of the FBLN3 gene.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Oct 17, 2015

References

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