Primary Sjögren’s syndrome (pSS) is a prototypic autoimmune disease characterized by immune injury to the salivary and lacrimal glands with other systemic manifestations. Recent studies showed the adaptive autoimmune responses induced by muscarinic acetylcholine 3 receptor (M3R) contribute to the dysfunction of exocrine glands in the pathogenesis of pSS. Although the M3R-induced mononuclear cells infiltration are observed in exocrine glands in pSS patients and animal models, the role of M3R in lymphatic vessels formation has not been explored. In current study, we found the expression of lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) increased in intestine of the M3R immunized mice and epidermal growth factor receptor (EGFR) mimotope could inhibit this behavior. Our results suggested that the M3R/EGFR transactivation signaling may help mononuclear cells infiltrate in exocrine glands by promoting lymphangiogenesis. Keywords Sjögren’s syndrome · Muscarinic acetylcholine 3 receptor · Epidermal growth factor receptor · Lymphangiogenesis Introduction glands. Previous studies showed periductal focal infiltra - tion of mononuclear cells can be observed in patients with Primary Sjögren’s syndrome (pSS) is a prototypic autoim- SS and these mononuclear cells are largely composed of mune disease characterized by immune injury to the sali- CD4+ T cells and B cells (Voulgarelis and Tzioufas 2010). vary
International Journal of Peptide Research and Therapeutics – Springer Journals
Published: May 31, 2018
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