EGFR Mimotope Reduces the Expression of LYVE-1 in the Intestine from the M3R Immunized Mice

EGFR Mimotope Reduces the Expression of LYVE-1 in the Intestine from the M3R Immunized Mice Primary Sjögren’s syndrome (pSS) is a prototypic autoimmune disease characterized by immune injury to the salivary and lacrimal glands with other systemic manifestations. Recent studies showed the adaptive autoimmune responses induced by muscarinic acetylcholine 3 receptor (M3R) contribute to the dysfunction of exocrine glands in the pathogenesis of pSS. Although the M3R-induced mononuclear cells infiltration are observed in exocrine glands in pSS patients and animal models, the role of M3R in lymphatic vessels formation has not been explored. In current study, we found the expression of lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) increased in intestine of the M3R immunized mice and epidermal growth factor receptor (EGFR) mimotope could inhibit this behavior. Our results suggested that the M3R/EGFR transactivation signaling may help mononuclear cells infiltrate in exocrine glands by promoting lymphangiogenesis. Keywords Sjögren’s syndrome · Muscarinic acetylcholine 3 receptor · Epidermal growth factor receptor · Lymphangiogenesis Introduction glands. Previous studies showed periductal focal infiltra - tion of mononuclear cells can be observed in patients with Primary Sjögren’s syndrome (pSS) is a prototypic autoim- SS and these mononuclear cells are largely composed of mune disease characterized by immune injury to the sali- CD4+ T cells and B cells (Voulgarelis and Tzioufas 2010). vary http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Peptide Research and Therapeutics Springer Journals

EGFR Mimotope Reduces the Expression of LYVE-1 in the Intestine from the M3R Immunized Mice

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Publisher
Springer Netherlands
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Life Sciences; Biochemistry, general; Animal Anatomy / Morphology / Histology; Polymer Sciences; Pharmaceutical Sciences/Technology; Pharmacology/Toxicology; Molecular Medicine
ISSN
1573-3149
eISSN
1573-3904
D.O.I.
10.1007/s10989-018-9722-9
Publisher site
See Article on Publisher Site

Abstract

Primary Sjögren’s syndrome (pSS) is a prototypic autoimmune disease characterized by immune injury to the salivary and lacrimal glands with other systemic manifestations. Recent studies showed the adaptive autoimmune responses induced by muscarinic acetylcholine 3 receptor (M3R) contribute to the dysfunction of exocrine glands in the pathogenesis of pSS. Although the M3R-induced mononuclear cells infiltration are observed in exocrine glands in pSS patients and animal models, the role of M3R in lymphatic vessels formation has not been explored. In current study, we found the expression of lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) increased in intestine of the M3R immunized mice and epidermal growth factor receptor (EGFR) mimotope could inhibit this behavior. Our results suggested that the M3R/EGFR transactivation signaling may help mononuclear cells infiltrate in exocrine glands by promoting lymphangiogenesis. Keywords Sjögren’s syndrome · Muscarinic acetylcholine 3 receptor · Epidermal growth factor receptor · Lymphangiogenesis Introduction glands. Previous studies showed periductal focal infiltra - tion of mononuclear cells can be observed in patients with Primary Sjögren’s syndrome (pSS) is a prototypic autoim- SS and these mononuclear cells are largely composed of mune disease characterized by immune injury to the sali- CD4+ T cells and B cells (Voulgarelis and Tzioufas 2010). vary

Journal

International Journal of Peptide Research and TherapeuticsSpringer Journals

Published: May 31, 2018

References

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