New functionalized 1,2,3-triazoloquinolines were achieved by intramolecular azide–alkyne Huisgen [3+2] cycloaddition. These derivatives were synthesized via the key Baylis–Hillman adduct under mild, neutral conditions in short duration and consistently good yield. The structures of final compounds were characterized by spectral analysis. Antifungal activities of these analogues against Trichophyton mentagrophytes, Candida albicans, and Aspergillus niger were also assayed.
Research on Chemical Intermediates – Springer Journals
Published: May 11, 2014
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