Efficient synthesis via azide–alkyne Huisgen [3+2] cycloaddition reaction and antifungal activity studies of novel triazoloquinolines

Efficient synthesis via azide–alkyne Huisgen [3+2] cycloaddition reaction and antifungal... New functionalized 1,2,3-triazoloquinolines were achieved by intramolecular azide–alkyne Huisgen [3+2] cycloaddition. These derivatives were synthesized via the key Baylis–Hillman adduct under mild, neutral conditions in short duration and consistently good yield. The structures of final compounds were characterized by spectral analysis. Antifungal activities of these analogues against Trichophyton mentagrophytes, Candida albicans, and Aspergillus niger were also assayed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Efficient synthesis via azide–alkyne Huisgen [3+2] cycloaddition reaction and antifungal activity studies of novel triazoloquinolines

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Publisher
Springer Netherlands
Copyright
Copyright © 2014 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-014-1638-1
Publisher site
See Article on Publisher Site

Abstract

New functionalized 1,2,3-triazoloquinolines were achieved by intramolecular azide–alkyne Huisgen [3+2] cycloaddition. These derivatives were synthesized via the key Baylis–Hillman adduct under mild, neutral conditions in short duration and consistently good yield. The structures of final compounds were characterized by spectral analysis. Antifungal activities of these analogues against Trichophyton mentagrophytes, Candida albicans, and Aspergillus niger were also assayed.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: May 11, 2014

References

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