Efficient synthesis of some new functionalized 3-amino- and 5-aminopyrazoles derivatives

Efficient synthesis of some new functionalized 3-amino- and 5-aminopyrazoles derivatives Cyanoacetic acid hydrazide derivatives were utilized as key intermediates for the synthesis of some new 3-amino- and 5-aminopyrazole derivatives. Coupling of N′-phenylsulfonyl-2-cyanoacetohydrazide (1) and 1-(2-cyanoacetyl)-4-phenyl thiosemicarbazide (4) with different aryl diazonium chlorides afforded the corresponding 5-amino-1-substituted-4-pyrazolin-3-one derivatives 3 and 6, respectively. Treatment of ketene dithioacetal 9 and ketene-N,S-acetal 13 with hydrazine and/or benzenesulfonyl hydrazide furnished the corresponding 3-amino-5-1H-pyrazole-4-carbohydrazide derivatives 10, 11, and 14. The structures of the new synthesized compounds were elucidated and confirmed by elemental analyses and spectral data. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Efficient synthesis of some new functionalized 3-amino- and 5-aminopyrazoles derivatives

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Springer Netherlands
Copyright © 2014 by Springer Science+Business Media Dordrecht
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
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