Efficient synthesis of novel quinazoline-4(1H)-one derivatives by N-halosulfonamides

Efficient synthesis of novel quinazoline-4(1H)-one derivatives by N-halosulfonamides O H R TBBDA and PBBS N H N O 2 N R R O 1 2 Reflux, EtOH/H O N R H 2 N O or H Or Solventless -100 C NH OAC R = NHCOR or H 3 1 R =aryl, alkyl R = aryl 1 2 0 0 Keywords N,N,N ,N -tetrabromobenzene-1,3-disulfonamide  Poly(N-bromo-N- ethylbenzene-1,3,5-disulfonamide  Quinazoline-4(1H)-one  Isatoic anhydride Acid hydrazide Electronic supplementary material The online version of this article (doi:10.1007/s11164-016-2678-5) contains supplementary material, which is available to authorized users. & Ramin Ghorbani-Vaghei rgvaghei@yahoo.com Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University, PO Box 65174, Hamedan, Iran 123 984 R. Ghorbani-Vaghei et al. Introduction According to literature survey, quinazolin-4 (1H)-one derivatives are well known as important and valuable physiological compounds containing various medical properties. For example, they are active against bacteria, fungi, and tumors or they have a mono amine oxidase inhibitor trait [1]. Also, quinazolin-4(1H)-ones can be converted to quinazolin-4(3H)-one derivatives, which are biologically active heterocyclic materials and can also be found in some natural products. Specifically, the quinazolinone core scaffold has been extensively used as a drug-like template in medicinal chemistry [2]. For example, some novel nonpeptide antagonists for formyl peptide http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Efficient synthesis of novel quinazoline-4(1H)-one derivatives by N-halosulfonamides

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Springer Netherlands
Copyright © 2016 by Springer Science+Business Media Dordrecht
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
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