Efficient synthesis of novel quinazoline-4(1H)-one derivatives by N-halosulfonamides

Efficient synthesis of novel quinazoline-4(1H)-one derivatives by N-halosulfonamides O H R TBBDA and PBBS N H N O 2 N R R O 1 2 Reflux, EtOH/H O N R H 2 N O or H Or Solventless -100 C NH OAC R = NHCOR or H 3 1 R =aryl, alkyl R = aryl 1 2 0 0 Keywords N,N,N ,N -tetrabromobenzene-1,3-disulfonamide  Poly(N-bromo-N- ethylbenzene-1,3,5-disulfonamide  Quinazoline-4(1H)-one  Isatoic anhydride Acid hydrazide Electronic supplementary material The online version of this article (doi:10.1007/s11164-016-2678-5) contains supplementary material, which is available to authorized users. & Ramin Ghorbani-Vaghei rgvaghei@yahoo.com Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University, PO Box 65174, Hamedan, Iran 123 984 R. Ghorbani-Vaghei et al. Introduction According to literature survey, quinazolin-4 (1H)-one derivatives are well known as important and valuable physiological compounds containing various medical properties. For example, they are active against bacteria, fungi, and tumors or they have a mono amine oxidase inhibitor trait [1]. Also, quinazolin-4(1H)-ones can be converted to quinazolin-4(3H)-one derivatives, which are biologically active heterocyclic materials and can also be found in some natural products. Specifically, the quinazolinone core scaffold has been extensively used as a drug-like template in medicinal chemistry [2]. For example, some novel nonpeptide antagonists for formyl peptide http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Efficient synthesis of novel quinazoline-4(1H)-one derivatives by N-halosulfonamides

Loading next page...
 
/lp/springer_journal/efficient-synthesis-of-novel-quinazoline-4-1h-one-derivatives-by-n-IHk0uHAczO
Publisher
Springer Netherlands
Copyright
Copyright © 2016 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-016-2678-5
Publisher site
See Article on Publisher Site

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial