Two series of novel urea and thiourea-based quinazoline derivatives (7a–g/8a–g) have been synthesized by Suzuki C–C coupling between the C2 position of quinazoline and a phenyl ring then condensation with N-phenyl isocyanates/isothiocyanates with good overall yields in a short reaction time. All the synthesized compounds were well characterized by IR, NMR, and elemental analysis. Synthesis of these 1-phenyl-3-(4-(4-(m-tolyloxy)quinazolin-2-yl)phenyl)urea/thiourea derivatives was conveniently achieved in only three steps, starting from 2,4-dichloroquinazoline.
Research on Chemical Intermediates – Springer Journals
Published: Aug 30, 2013
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