Efficient palladium-catalyzed Suzuki C–C coupling of novel urea/thiourea-based quinazolines

Efficient palladium-catalyzed Suzuki C–C coupling of novel urea/thiourea-based quinazolines Two series of novel urea and thiourea-based quinazoline derivatives (7a–g/8a–g) have been synthesized by Suzuki C–C coupling between the C2 position of quinazoline and a phenyl ring then condensation with N-phenyl isocyanates/isothiocyanates with good overall yields in a short reaction time. All the synthesized compounds were well characterized by IR, NMR, and elemental analysis. Synthesis of these 1-phenyl-3-(4-(4-(m-tolyloxy)quinazolin-2-yl)phenyl)urea/thiourea derivatives was conveniently achieved in only three steps, starting from 2,4-dichloroquinazoline. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Efficient palladium-catalyzed Suzuki C–C coupling of novel urea/thiourea-based quinazolines

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Springer Netherlands
Copyright © 2013 by Springer Science+Business Media Dordrecht
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
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