In this work, the efficient and selective preparation of amides from arylamines and esters has been performed successfully with an AlCl 3 /Et 3 N pair under mild conditions. A large number of arylamines were acylated to the corresponding amides with high yields and short reaction times. In addition, a computational study on the N-acylation of amines has been carried out using the density functional theory (DFT) method.(Figure not available: see fulltext.)
Research on Chemical Intermediates – Springer Journals
Published: Mar 6, 2012
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