Efficacy and safety of methotrexate plus certolizumab pegol or placebo in active rheumatoid arthritis

Efficacy and safety of methotrexate plus certolizumab pegol or placebo in active rheumatoid... Originalien 1 2 Z Rheumatol 2017 · 76:528–534 Y. H. Lee · S.-C. Bae DOI 10.1007/s00393-016-0133-z Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Seoul, Published online: 16 June 2016 Korea © Springer-Verlag Berlin Heidelberg 2016 Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea Redaktion U. Müller-Ladner, Bad Nauheim U. Lange, Bad Nauheim Efficacy and safety of methotrexate plus certolizumab pegol or placebo in active rheumatoid arthritis Meta-analysis of randomized controlled trials of CZP to 14 days and may increase Introduction Methods the preferential distribution of CZP to Rheumatoid arthritis (RA) is a systemic inflamed tissues [8]. Identification of eligible studies autoimmune disease characterized by Several clinical trials have attempted and data extraction chronic synovial joint inflammation, to evaluate the efficacy and safety of which leads to disability and loss of CZP + MTX in patients with active RA We performed an exhaustive literature quality of life [1, 2]. Tumor necrosis who had an incomplete response to MTX search using PubMed, EMBASE, and factor-α (TNF-α) is a potent pro-inflam- ordisease-modifyingantirheumaticdrug theCochraneControlled Trials Regis- matory cytokine that plays an important (DMARD) [9–14]. A previous meta- ter to identify available articles (up to role in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Zeitschrift für Rheumatologie Springer Journals

Efficacy and safety of methotrexate plus certolizumab pegol or placebo in active rheumatoid arthritis

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Publisher
Springer Medizin
Copyright
Copyright © 2016 by Springer-Verlag Berlin Heidelberg
Subject
Medicine & Public Health; Internal Medicine; Rheumatology
ISSN
0340-1855
eISSN
1435-1250
D.O.I.
10.1007/s00393-016-0133-z
Publisher site
See Article on Publisher Site

Abstract

Originalien 1 2 Z Rheumatol 2017 · 76:528–534 Y. H. Lee · S.-C. Bae DOI 10.1007/s00393-016-0133-z Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Seoul, Published online: 16 June 2016 Korea © Springer-Verlag Berlin Heidelberg 2016 Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea Redaktion U. Müller-Ladner, Bad Nauheim U. Lange, Bad Nauheim Efficacy and safety of methotrexate plus certolizumab pegol or placebo in active rheumatoid arthritis Meta-analysis of randomized controlled trials of CZP to 14 days and may increase Introduction Methods the preferential distribution of CZP to Rheumatoid arthritis (RA) is a systemic inflamed tissues [8]. Identification of eligible studies autoimmune disease characterized by Several clinical trials have attempted and data extraction chronic synovial joint inflammation, to evaluate the efficacy and safety of which leads to disability and loss of CZP + MTX in patients with active RA We performed an exhaustive literature quality of life [1, 2]. Tumor necrosis who had an incomplete response to MTX search using PubMed, EMBASE, and factor-α (TNF-α) is a potent pro-inflam- ordisease-modifyingantirheumaticdrug theCochraneControlled Trials Regis- matory cytokine that plays an important (DMARD) [9–14]. A previous meta- ter to identify available articles (up to role in

Journal

Zeitschrift für RheumatologieSpringer Journals

Published: Jun 16, 2016

References

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