Rationale Cigarette demand is a behavioral economic mea- ed in similar reductions in cigarette reinforcement. Larger ini- sure of the relative value of cigarettes. Decreasing the value tial reductions in demand on quit day were associated with of cigarette reinforcement may help with quitting smoking. early success with abstaining from cigarettes. Behavioral eco- Objectives This study aimed to evaluate the effects of initial nomic approaches may be useful for identifying individuals use of varenicline (VAR) versus nicotine replacement therapy who benefit less from pharmacotherapy and may need addi- (NRT) on demand for cigarettes on quit day among smokers tional treatment resources. with substance use disorders (SUD) and to determine whether Trial registration https://clinicaltrials.gov/ct2/show/ reduced demand was associated with subsequent abstinence NCT00756275 from smoking at 1 and 3 months. Methods Participants (N = 110) were randomized to double- . . blind, double-placebo conditions: VAR with placebo NRT or Keywords Smoking Nicotine dependence Behavioral . . . economics Varenicline Nicotine replacement therapy NRTwith placebo capsules. The cigarette purchase task (CPT) . . was used to assess demand for cigarettes at baseline and on Cigarette purchase task Substance use disorders Abstinence quit day, following a 1-week medication dose run-up/placebo capsule lead-in and
Psychopharmacology – Springer Journals
Published: May 13, 2017
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