Effects of varenicline versus transdermal nicotine replacement therapy on cigarette demand on quit day in individuals with substance use disorders

Effects of varenicline versus transdermal nicotine replacement therapy on cigarette demand on... Rationale Cigarette demand is a behavioral economic mea- ed in similar reductions in cigarette reinforcement. Larger ini- sure of the relative value of cigarettes. Decreasing the value tial reductions in demand on quit day were associated with of cigarette reinforcement may help with quitting smoking. early success with abstaining from cigarettes. Behavioral eco- Objectives This study aimed to evaluate the effects of initial nomic approaches may be useful for identifying individuals use of varenicline (VAR) versus nicotine replacement therapy who benefit less from pharmacotherapy and may need addi- (NRT) on demand for cigarettes on quit day among smokers tional treatment resources. with substance use disorders (SUD) and to determine whether Trial registration https://clinicaltrials.gov/ct2/show/ reduced demand was associated with subsequent abstinence NCT00756275 from smoking at 1 and 3 months. Methods Participants (N = 110) were randomized to double- . . blind, double-placebo conditions: VAR with placebo NRT or Keywords Smoking Nicotine dependence Behavioral . . . economics Varenicline Nicotine replacement therapy NRTwith placebo capsules. The cigarette purchase task (CPT) . . was used to assess demand for cigarettes at baseline and on Cigarette purchase task Substance use disorders Abstinence quit day, following a 1-week medication dose run-up/placebo capsule lead-in and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Effects of varenicline versus transdermal nicotine replacement therapy on cigarette demand on quit day in individuals with substance use disorders

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Subject
Biomedicine; Neurosciences; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
D.O.I.
10.1007/s00213-017-4635-4
Publisher site
See Article on Publisher Site

Abstract

Rationale Cigarette demand is a behavioral economic mea- ed in similar reductions in cigarette reinforcement. Larger ini- sure of the relative value of cigarettes. Decreasing the value tial reductions in demand on quit day were associated with of cigarette reinforcement may help with quitting smoking. early success with abstaining from cigarettes. Behavioral eco- Objectives This study aimed to evaluate the effects of initial nomic approaches may be useful for identifying individuals use of varenicline (VAR) versus nicotine replacement therapy who benefit less from pharmacotherapy and may need addi- (NRT) on demand for cigarettes on quit day among smokers tional treatment resources. with substance use disorders (SUD) and to determine whether Trial registration https://clinicaltrials.gov/ct2/show/ reduced demand was associated with subsequent abstinence NCT00756275 from smoking at 1 and 3 months. Methods Participants (N = 110) were randomized to double- . . blind, double-placebo conditions: VAR with placebo NRT or Keywords Smoking Nicotine dependence Behavioral . . . economics Varenicline Nicotine replacement therapy NRTwith placebo capsules. The cigarette purchase task (CPT) . . was used to assess demand for cigarettes at baseline and on Cigarette purchase task Substance use disorders Abstinence quit day, following a 1-week medication dose run-up/placebo capsule lead-in and

Journal

PsychopharmacologySpringer Journals

Published: May 13, 2017

References

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