J Gastroenterol (2017) 52:1051–1063 DOI 10.1007/s00535-017-1316-3 O R I G IN AL ARTI CL E—LIV E R, PA NCREA S , A ND BIL I ARY T RA CT Effects of vaccine-acquired polyclonal anti-HBs antibodies on the prevention of HBV infection of non-vaccine genotypes 1,2 3 4 5 • • • • Masaki Kato Susumu Hamada-Tsutsumi Chiaki Okuse Aiko Sakai 2 6 6 6 • • • • Nobuyuki Matsumoto Masaaki Sato Toshiyuki Sato Mitsumi Arito 6 6 6 7 • • • • Kazuki Omoteyama Naoya Suematsu Kazuki Okamoto Takanobu Kato 2 5 3 8 • • • • Fumio Itoh Ryo Sumazaki Yasuhito Tanaka Hiroshi Yotsuyanagi 6 1 Tomohiro Kato Manae Suzuki Kurokawa Received: 8 November 2016 / Accepted: 31 January 2017 / Published online: 14 February 2017 Japanese Society of Gastroenterology 2017 Abstract measured by ELISA. The capacity of sera to neutralize Background In universal hepatitis B (HB) vaccination, HBV was evaluated using an in vitro infection model. single vaccine-derived polyclonal anti-HBs antibodies Results Of 135 anti-gtA-Ag-reactive gtA-sera, 134 (anti-HBs) need to inhibit infection of HB viruses (HBV) (99.3%) were anti-gtC-Ag-reactive. All (100%) 120 anti- of non-vaccine genotypes. We experimentally addressed gtC-Ag-reactive gtC-sera were anti-gtA-Ag-reactive. The
Journal of Gastroenterology – Springer Journals
Published: Feb 14, 2017
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