Effects of the serotonin 2C receptor agonist WAY163909 on the abuse-related effects and mesolimbic dopamine neurochemistry induced by abused stimulants in rhesus monkeys

Effects of the serotonin 2C receptor agonist WAY163909 on the abuse-related effects and... Psychopharmacology (2017) 234:2607–2617 DOI 10.1007/s00213-017-4653-2 ORIGINAL INVESTIGATION Effects of the serotonin 2C receptor agonist WAY163909 on the abuse-related effects and mesolimbic dopamine neurochemistry induced by abused stimulants in rhesus monkeys 1,2,3 1,3 1,3 1,3 Laís F. Berro & Maylen Perez Diaz & Eric Maltbie & Leonard L. Howell Received: 30 August 2016 /Accepted: 19 May 2017 /Published online: 5 June 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract dependent attenuation of cocaine- or methamphetamine- Rationale Accumulating evidence shows that the serotoner- induced dopamine overflow in the nucleus accumbens. gic system plays a major role in psychostimulant abuse Conclusions Our data indicate that selective 5-HT receptor 2C through its interactions with the dopaminergic system. activation decreases drug intake and drug-seeking behavior in Studies indicate that serotonin 5-HT receptors are one of nonhuman primate models of psychostimulant abuse through 2C the main classes of receptors involved in mediating the influ- neurochemical mechanisms involved in the modulation of ence of serotonin in drug abuse. mesolimbic dopamine. Objective The aim of the present study was to evaluate the . . effects of the selective serotonin 5-HT receptor agonist Keywords Cocaine Methamphetamine 2C . . . WAY163909 on the behavioral neuropharmacology of co- Self-administration Reinstatement In http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Effects of the serotonin 2C receptor agonist WAY163909 on the abuse-related effects and mesolimbic dopamine neurochemistry induced by abused stimulants in rhesus monkeys

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Subject
Biomedicine; Neurosciences; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
D.O.I.
10.1007/s00213-017-4653-2
Publisher site
See Article on Publisher Site

Abstract

Psychopharmacology (2017) 234:2607–2617 DOI 10.1007/s00213-017-4653-2 ORIGINAL INVESTIGATION Effects of the serotonin 2C receptor agonist WAY163909 on the abuse-related effects and mesolimbic dopamine neurochemistry induced by abused stimulants in rhesus monkeys 1,2,3 1,3 1,3 1,3 Laís F. Berro & Maylen Perez Diaz & Eric Maltbie & Leonard L. Howell Received: 30 August 2016 /Accepted: 19 May 2017 /Published online: 5 June 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract dependent attenuation of cocaine- or methamphetamine- Rationale Accumulating evidence shows that the serotoner- induced dopamine overflow in the nucleus accumbens. gic system plays a major role in psychostimulant abuse Conclusions Our data indicate that selective 5-HT receptor 2C through its interactions with the dopaminergic system. activation decreases drug intake and drug-seeking behavior in Studies indicate that serotonin 5-HT receptors are one of nonhuman primate models of psychostimulant abuse through 2C the main classes of receptors involved in mediating the influ- neurochemical mechanisms involved in the modulation of ence of serotonin in drug abuse. mesolimbic dopamine. Objective The aim of the present study was to evaluate the . . effects of the selective serotonin 5-HT receptor agonist Keywords Cocaine Methamphetamine 2C . . . WAY163909 on the behavioral neuropharmacology of co- Self-administration Reinstatement In

Journal

PsychopharmacologySpringer Journals

Published: Jun 5, 2017

References

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