Psychopharmacology (2017) 234:2607–2617 DOI 10.1007/s00213-017-4653-2 ORIGINAL INVESTIGATION Effects of the serotonin 2C receptor agonist WAY163909 on the abuse-related effects and mesolimbic dopamine neurochemistry induced by abused stimulants in rhesus monkeys 1,2,3 1,3 1,3 1,3 Laís F. Berro & Maylen Perez Diaz & Eric Maltbie & Leonard L. Howell Received: 30 August 2016 /Accepted: 19 May 2017 /Published online: 5 June 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract dependent attenuation of cocaine- or methamphetamine- Rationale Accumulating evidence shows that the serotoner- induced dopamine overflow in the nucleus accumbens. gic system plays a major role in psychostimulant abuse Conclusions Our data indicate that selective 5-HT receptor 2C through its interactions with the dopaminergic system. activation decreases drug intake and drug-seeking behavior in Studies indicate that serotonin 5-HT receptors are one of nonhuman primate models of psychostimulant abuse through 2C the main classes of receptors involved in mediating the influ- neurochemical mechanisms involved in the modulation of ence of serotonin in drug abuse. mesolimbic dopamine. Objective The aim of the present study was to evaluate the . . effects of the selective serotonin 5-HT receptor agonist Keywords Cocaine Methamphetamine 2C . . . WAY163909 on the behavioral neuropharmacology of co- Self-administration Reinstatement In
Psychopharmacology – Springer Journals
Published: Jun 5, 2017
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