Access the full text.
Sign up today, get DeepDyve free for 14 days.
Clin Pharmacokinet (2018) 57:729–737 https://doi.org/10.1007/s40262-017-0591-8 OR IGINAL RESEARCH ARTIC L E Effects of the Proton Pump Inhibitors Omeprazole and Pantoprazole on the Cytochrome P450-Mediated Metabolism of Venlafaxine 1,2 1,2,5 3,4 • • • Maxim Kuzin Georgios Schoretsanitis Ekkehard Haen 3,4 6,7 1,2 • • • Benedikt Stegmann Christoph Hiemke Gerhard Gru ¨ nder 1,2,8 Michael Paulzen Published online: 2 September 2017 Springer International Publishing AG 2017 Abstract venlafaxine, O-desmethylvenlafaxine and active moiety Background and Objective An increasing trend in pre- (venlafaxine ? O-desmethylvenlafaxine), as well as dose- scribing proton pump inhibitors (PPIs) inevitably increases adjusted plasma concentrations, were compared using non- the risk of unwanted drug–drug interactions (DDIs). The parametrical tests. aim of this study was to uncover pharmacokinetic inter- Results Daily doses of venlafaxine did not differ between actions between two PPIs—omeprazole and pantopra- groups (p = 0.949). The Mann–Whitney U test showed sig- zole—and venlafaxine. nificantly higher plasma concentrations of active moiety, as Methods A therapeutic drug monitoring database con- well as venlafaxine and O-desmethylvenlafaxine, in both PPI tained plasma concentrations of venlafaxine and its active groups [p = 0.023, p = 0.011, p = 0.026, ?29% active metabolite O-desmethylvenlafaxine. We considered three moiety, ?27% venlafaxine, ?36%
Clinical Pharmacokinetics – Springer Journals
Published: Sep 2, 2017
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.