Effects of tetramethylpyrazine phosphate on pancreatic islet microcirculation in SD rats

Effects of tetramethylpyrazine phosphate on pancreatic islet microcirculation in SD rats J Endocrinol Invest (2018) 41:411–419 https://doi.org/10.1007/s40618-017-0748-1 ORIGINAL ARTICLE Effects of tetramethylpyrazine phosphate on pancreatic islet microcirculation in SD rats 1,2 3 1 1,2 1,2 1,2 X. Xu  · L. Wu  · Z. Q. Lu  · P. Xia  · X. P. Zhu  · X. Gao   Received: 4 February 2017 / Accepted: 19 August 2017 / Published online: 16 September 2017 © Italian Society of Endocrinology (SIE) 2017 Abstract 30% glucose subgroups than the 15% ones. In 30% glucose- Purposes Abnormal islet microcirculation impetus the treated subgroups, TMPP improved the blood glucose con- insulin production and accelerates progression of Type 1 and centration by 10%, compared with the control (19.3 ± 0.64 2 diabetes. In this study, we investigated whether tetrameth- vs 17.32  ±  0.56  mmol/l, P  <  0.05), without influencing ylpyrazine phosphate (TMPP), a vasoactive substance, could the insulin secretion. Blocking NO formation prevented regulate the islet microcirculation and insulin concentration the enhanced PBF and IBF, evoking by TMPP with 30% and improve glycaemia in SD rats. glucose. Methods SD rats were randomly divided into two groups, Conclusions TMPP can regulate the pancreatic islet micro- the control and TMPP groups. Each group was further circulation and possess a hypoglycemia effect after glucose divided into three subgroups according to the intravenous infusion through http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Endocrinological Investigation Springer Journals

Effects of tetramethylpyrazine phosphate on pancreatic islet microcirculation in SD rats

Loading next page...
 
/lp/springer_journal/effects-of-tetramethylpyrazine-phosphate-on-pancreatic-islet-CJwWvsML0X
Publisher
Springer International Publishing
Copyright
Copyright © 2017 by Italian Society of Endocrinology (SIE)
Subject
Medicine & Public Health; Medicine/Public Health, general; Endocrinology; Metabolic Diseases
eISSN
1720-8386
D.O.I.
10.1007/s40618-017-0748-1
Publisher site
See Article on Publisher Site

Abstract

J Endocrinol Invest (2018) 41:411–419 https://doi.org/10.1007/s40618-017-0748-1 ORIGINAL ARTICLE Effects of tetramethylpyrazine phosphate on pancreatic islet microcirculation in SD rats 1,2 3 1 1,2 1,2 1,2 X. Xu  · L. Wu  · Z. Q. Lu  · P. Xia  · X. P. Zhu  · X. Gao   Received: 4 February 2017 / Accepted: 19 August 2017 / Published online: 16 September 2017 © Italian Society of Endocrinology (SIE) 2017 Abstract 30% glucose subgroups than the 15% ones. In 30% glucose- Purposes Abnormal islet microcirculation impetus the treated subgroups, TMPP improved the blood glucose con- insulin production and accelerates progression of Type 1 and centration by 10%, compared with the control (19.3 ± 0.64 2 diabetes. In this study, we investigated whether tetrameth- vs 17.32  ±  0.56  mmol/l, P  <  0.05), without influencing ylpyrazine phosphate (TMPP), a vasoactive substance, could the insulin secretion. Blocking NO formation prevented regulate the islet microcirculation and insulin concentration the enhanced PBF and IBF, evoking by TMPP with 30% and improve glycaemia in SD rats. glucose. Methods SD rats were randomly divided into two groups, Conclusions TMPP can regulate the pancreatic islet micro- the control and TMPP groups. Each group was further circulation and possess a hypoglycemia effect after glucose divided into three subgroups according to the intravenous infusion through

Journal

Journal of Endocrinological InvestigationSpringer Journals

Published: Sep 16, 2017

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial