J Endocrinol Invest (2018) 41:411–419 https://doi.org/10.1007/s40618-017-0748-1 ORIGINAL ARTICLE Effects of tetramethylpyrazine phosphate on pancreatic islet microcirculation in SD rats 1,2 3 1 1,2 1,2 1,2 X. Xu · L. Wu · Z. Q. Lu · P. Xia · X. P. Zhu · X. Gao Received: 4 February 2017 / Accepted: 19 August 2017 / Published online: 16 September 2017 © Italian Society of Endocrinology (SIE) 2017 Abstract 30% glucose subgroups than the 15% ones. In 30% glucose- Purposes Abnormal islet microcirculation impetus the treated subgroups, TMPP improved the blood glucose con- insulin production and accelerates progression of Type 1 and centration by 10%, compared with the control (19.3 ± 0.64 2 diabetes. In this study, we investigated whether tetrameth- vs 17.32 ± 0.56 mmol/l, P < 0.05), without influencing ylpyrazine phosphate (TMPP), a vasoactive substance, could the insulin secretion. Blocking NO formation prevented regulate the islet microcirculation and insulin concentration the enhanced PBF and IBF, evoking by TMPP with 30% and improve glycaemia in SD rats. glucose. Methods SD rats were randomly divided into two groups, Conclusions TMPP can regulate the pancreatic islet micro- the control and TMPP groups. Each group was further circulation and possess a hypoglycemia effect after glucose divided into three subgroups according to the intravenous infusion through
Journal of Endocrinological Investigation – Springer Journals
Published: Sep 16, 2017
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