A study was made of three insertional mutations (Trl 13C,Trl s2325,Trl EP(3)3184) located in the second intron of the Trithorax-like(Trl) gene for the GAGA transcription factor (GAF). Their cytological effects were analyzed in oogenesis, early embryonic development, and in larval development (96–108 h) in cells of nervous ganglia and imaginal disks. Notwithstanding an interallelic difference in expression, all three P-element insertions proved to be dominant as far as the examined parameters were concerned. The most substantial defects were the formation of “granular” chromatin during the interphase and mitosis and high proportions of cells with hypercondensed chromatin (which were arrested at the G2–M boundary) and cells with abnormal chromosome segregation. A higher frequency of egg chambers with trophocytes defective in number and in chromatin condensation was observed in females carrying the mutant Trlgene. The defects were assumed to result from poor coordination of the chromosome and cell cycles and, including, the nuclear and centrosomal cycles in embryonic development and the cycles of chromosome condensation and spindle formation in cells of larval imaginal disks and nervous ganglia.
Russian Journal of Genetics – Springer Journals
Published: Oct 16, 2004
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