Effects of SomeTrlMutations on Mitosis in Embryonic and Larval Tissues and Egg Chamber Morphology in Drosophila melanogaster

Effects of SomeTrlMutations on Mitosis in Embryonic and Larval Tissues and Egg Chamber Morphology... A study was made of three insertional mutations (Trl 13C,Trl s2325,Trl EP(3)3184) located in the second intron of the Trithorax-like(Trl) gene for the GAGA transcription factor (GAF). Their cytological effects were analyzed in oogenesis, early embryonic development, and in larval development (96–108 h) in cells of nervous ganglia and imaginal disks. Notwithstanding an interallelic difference in expression, all three P-element insertions proved to be dominant as far as the examined parameters were concerned. The most substantial defects were the formation of “granular” chromatin during the interphase and mitosis and high proportions of cells with hypercondensed chromatin (which were arrested at the G2–M boundary) and cells with abnormal chromosome segregation. A higher frequency of egg chambers with trophocytes defective in number and in chromatin condensation was observed in females carrying the mutant Trlgene. The defects were assumed to result from poor coordination of the chromosome and cell cycles and, including, the nuclear and centrosomal cycles in embryonic development and the cycles of chromosome condensation and spindle formation in cells of larval imaginal disks and nervous ganglia. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Effects of SomeTrlMutations on Mitosis in Embryonic and Larval Tissues and Egg Chamber Morphology in Drosophila melanogaster

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Publisher
Springer Journals
Copyright
Copyright © 2001 by MAIK “Nauka/Interperiodica”
Subject
Biomedicine; Human Genetics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1023/A:1013283510095
Publisher site
See Article on Publisher Site

Abstract

A study was made of three insertional mutations (Trl 13C,Trl s2325,Trl EP(3)3184) located in the second intron of the Trithorax-like(Trl) gene for the GAGA transcription factor (GAF). Their cytological effects were analyzed in oogenesis, early embryonic development, and in larval development (96–108 h) in cells of nervous ganglia and imaginal disks. Notwithstanding an interallelic difference in expression, all three P-element insertions proved to be dominant as far as the examined parameters were concerned. The most substantial defects were the formation of “granular” chromatin during the interphase and mitosis and high proportions of cells with hypercondensed chromatin (which were arrested at the G2–M boundary) and cells with abnormal chromosome segregation. A higher frequency of egg chambers with trophocytes defective in number and in chromatin condensation was observed in females carrying the mutant Trlgene. The defects were assumed to result from poor coordination of the chromosome and cell cycles and, including, the nuclear and centrosomal cycles in embryonic development and the cycles of chromosome condensation and spindle formation in cells of larval imaginal disks and nervous ganglia.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Oct 16, 2004

References

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