Psychopharmacology (2017) 234:2673–2682 DOI 10.1007/s00213-017-4658-x ORIGINAL INVESTIGATION Effects of social reorganization on dopamine D2/D3 receptor availability and cocaine self-administration in male cynomolgus monkeys 1 1 2 1,2 P. W. Czoty & R. W. Gould & H. D. Gage & M. A. Nader Received: 4 January 2017 /Accepted: 21 May 2017 /Published online: 12 June 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract groups. However, when compared to their previous cocaine Rationale Studies have demonstrated that brain dopamine self-administration data, the potency of cocaine as a reinforcer D2/D3 receptors (D2/D3R) and the reinforcing effects of co- decreased in 9 of 11 monkeys. caine can be influenced by a monkey’s position in the social Conclusions These results indicate that changing the social dominance hierarchy. conditions can alter D2/D3R availability in subordinate mon- Objective In this study, we manipulated the social ranks of keys in a manner suggestive of environmental enrichment. In monkeys by reorganizing social groups and assessed effects most monkeys, social reorganization shifted the cocaine dose- on D2/D3R availability and cocaine self-administration. response curve to the right, also consistent with environmental Methods Male cynomolgus monkeys (N =12) hadbeen enrichment. trained to self-administer cocaine under a concurrent . . . cocaine-food reinforcement schedule.
Psychopharmacology – Springer Journals
Published: Jun 12, 2017
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