Effects of S-Nitrosoglutathione on Electrophysiological Manifestations of Mechanoelectric Feedback

Effects of S-Nitrosoglutathione on Electrophysiological Manifestations of Mechanoelectric Feedback 2+ Electromechanical coupling studies have described the intervention of nitric oxide and S-nitrosylation processes in Ca release induced by stretch, with heterogeneous findings. On the other hand, ion channel function activated by stretch is influ- enced by nitric oxide, and concentration-dependent biphasic effects upon several cellular functions have been described. The present study uses isolated and perfused rabbit hearts to investigate the changes in mechanoelectric feedback produced by two different concentrations of the nitric oxide carrier S -nitrosoglutathione. Epicardial multielectrodes were used to record myocardial activation at baseline and during and after left ventricular free wall stretch using an intraventricular device. Three experimental series were studied: (a) control (n = 10); (b) S-nitrosoglutathione 10 µM (n = 11); and (c) S-nitrosoglutathione 50 µM (n = 11). The changes in ventricular fibrillation (VF) pattern induced by stretch were analyzed and compared. S -nitroso- glutathione 10 µM did not modify VF at baseline, but attenuated acceleration of the arrhythmia (15.6 ± 1.7 vs. 21.3 ± 3.8 Hz; p < 0.0001) and reduction of percentile 5 of the activation intervals (42 ± 3 vs. 38 ± 4 ms; p < 0.05) induced by stretch. In contrast, at baseline using the 50 µM concentration, percentile 5 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cardiovascular Toxicology Springer Journals

Effects of S-Nitrosoglutathione on Electrophysiological Manifestations of Mechanoelectric Feedback

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Publisher
Springer US
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Biomedicine; Pharmacology/Toxicology; Cardiology
ISSN
1530-7905
eISSN
1559-0259
D.O.I.
10.1007/s12012-018-9463-1
Publisher site
See Article on Publisher Site

Abstract

2+ Electromechanical coupling studies have described the intervention of nitric oxide and S-nitrosylation processes in Ca release induced by stretch, with heterogeneous findings. On the other hand, ion channel function activated by stretch is influ- enced by nitric oxide, and concentration-dependent biphasic effects upon several cellular functions have been described. The present study uses isolated and perfused rabbit hearts to investigate the changes in mechanoelectric feedback produced by two different concentrations of the nitric oxide carrier S -nitrosoglutathione. Epicardial multielectrodes were used to record myocardial activation at baseline and during and after left ventricular free wall stretch using an intraventricular device. Three experimental series were studied: (a) control (n = 10); (b) S-nitrosoglutathione 10 µM (n = 11); and (c) S-nitrosoglutathione 50 µM (n = 11). The changes in ventricular fibrillation (VF) pattern induced by stretch were analyzed and compared. S -nitroso- glutathione 10 µM did not modify VF at baseline, but attenuated acceleration of the arrhythmia (15.6 ± 1.7 vs. 21.3 ± 3.8 Hz; p < 0.0001) and reduction of percentile 5 of the activation intervals (42 ± 3 vs. 38 ± 4 ms; p < 0.05) induced by stretch. In contrast, at baseline using the 50 µM concentration, percentile 5

Journal

Cardiovascular ToxicologySpringer Journals

Published: Jun 4, 2018

References

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