Effects of papaverine on healing of colonic anastomosis in rats

Effects of papaverine on healing of colonic anastomosis in rats original article Eur Surg (2017) 49:158–164 DOI 10.1007/s10353-017-0481-1 Effects of papaverine on healing of colonic anastomosis in rats Salim Ilksen Basceken · Yusuf Sevim · Cihangir Akyol · Egemen Cicek · Ferit Aydın · Akin Firat Kocaay · Ozge Tugce Pasaoglu · Volkan Genc · Hatice Pasaoglu · Atil Cakmak Received: 1 December 2016 / Accepted: 25 May 2017 / Published online: 12 June 2017 © Springer-Verlag Wien 2017 Summary and anastomosis group; ischemia-reperfusion and Background Anastomotic leak is the most devastating anastomosis + intraperitoneal one dose papaver- complication after colorectal surgery, and the blood ine group; and ischemia-reperfusion and anastomo- supply is a very important factor in anastomotic heal- sis + intraperitoneal daily (10 days) papaverine group. ing. Papaverine is a vasodilatory and antispasmodic Anastomotic bursting pressures, the hydroxyproline agent which has been used in many ischemic condi- measurements and macroscopic adhesion gradings tions because of its potentially protective effects. The were evaluated. aim of this study is to investigate the effects of pa- Results There was a significant difference between pa- paverine on healing colon anastomosis. paverine-administered groups and ischemia-reperfu- Methods Forty 8- to 10-week-old female Wistar Albino sion and anastomosis group for anastomotic bursting rats were http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Surgery Springer Journals

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Springer Vienna
Copyright © 2017 by Springer-Verlag Wien
Medicine & Public Health; Surgery; Abdominal Surgery; Cardiac Surgery; General Surgery; Vascular Surgery
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