Effects of oseltamivir phosphate (Tamiflu ® ) in human sera on results of microneutralization and hemagglutinin-inhibition tests for H5N2 avian influenza virus

Effects of oseltamivir phosphate (Tamiflu ® ) in human sera on results of microneutralization... To determine the influence of oseltamivir phosphate (Tamiflu ® ) on the results of microneutralization and hemagglutinin-inhibition (HI) tests in human sera with H5N2 influenza virus, ten volunteers were administered Tamiflu ® and blood samples were collected. In the microneutralization test, no consistent effects were observed. However, in the HI test, specimens from all volunteers taken at 4 and 7 h after drug administration showed a higher titer as compared to 0 and 24 h after administration when mammalian cells (horse, guinea pig, and human) were used. These results suggest that the administration of Tamiflu ® may affect the results of HI tests for H5N2 virus. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Effects of oseltamivir phosphate (Tamiflu ® ) in human sera on results of microneutralization and hemagglutinin-inhibition tests for H5N2 avian influenza virus

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Publisher
Springer Vienna
Copyright
Copyright © 2008 by Springer-Verlag
Subject
Biomedicine; Infectious Diseases; Medical Microbiology ; Virology
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-008-0038-5
Publisher site
See Article on Publisher Site

Abstract

To determine the influence of oseltamivir phosphate (Tamiflu ® ) on the results of microneutralization and hemagglutinin-inhibition (HI) tests in human sera with H5N2 influenza virus, ten volunteers were administered Tamiflu ® and blood samples were collected. In the microneutralization test, no consistent effects were observed. However, in the HI test, specimens from all volunteers taken at 4 and 7 h after drug administration showed a higher titer as compared to 0 and 24 h after administration when mammalian cells (horse, guinea pig, and human) were used. These results suggest that the administration of Tamiflu ® may affect the results of HI tests for H5N2 virus.

Journal

Archives of VirologySpringer Journals

Published: May 1, 2008

References

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