To determine the influence of oseltamivir phosphate (Tamiflu ® ) on the results of microneutralization and hemagglutinin-inhibition (HI) tests in human sera with H5N2 influenza virus, ten volunteers were administered Tamiflu ® and blood samples were collected. In the microneutralization test, no consistent effects were observed. However, in the HI test, specimens from all volunteers taken at 4 and 7 h after drug administration showed a higher titer as compared to 0 and 24 h after administration when mammalian cells (horse, guinea pig, and human) were used. These results suggest that the administration of Tamiflu ® may affect the results of HI tests for H5N2 virus.
Archives of Virology – Springer Journals
Published: May 1, 2008
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