Effects of nalfurafine on the reinforcing, thermal antinociceptive, and respiratory-depressant effects of oxycodone: modeling an abuse-deterrent opioid analgesic in rats

Effects of nalfurafine on the reinforcing, thermal antinociceptive, and respiratory-depressant... Psychopharmacology (2017) 234:2597–2605 DOI 10.1007/s00213-017-4652-3 ORIGINAL INVESTIGATION Effects of nalfurafine on the reinforcing, thermal antinociceptive, and respiratory-depressant effects of oxycodone: modeling an abuse-deterrent opioid analgesic in rats 1,2 3 4 5 E. Andrew Townsend & Jennifer E. Naylor & S. Stevens Negus & Shelley R. Edwards & 5 6 7,8 Hina N. Qureshi & Hunter W. McLendon & Christopher R. McCurdy & 7 9 9 9 Coco N. Kapanda & Jussara M. do Carmo & Fernanda S. da Silva & John E. Hall & 10 2 Kenneth J. Sufka & Kevin B. Freeman Received: 18 April 2017 /Accepted: 19 May 2017 /Published online: 31 May 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract effect functions were each determined for oxycodone, Rationale Strategies to reduce the misuse of mu opioid ago- nalfurafine, and the same oxycodone/nalfurafine mixture pro- nists are critically needed. Previous work has shown that kap- portions. Finally, the respiratory-depressant effects of equi- pa opioid agonists can diminish the abuse-related effects and antinociceptive doses of oxycodone, nalfurafine, and the mix- augment the antinociceptive effects of mu agonists. However, tures were compared. use of traditional kappa agonists is limited by their dysphoric Results Nalfurafine decreased the reinforcing effects of oxy- side http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Effects of nalfurafine on the reinforcing, thermal antinociceptive, and respiratory-depressant effects of oxycodone: modeling an abuse-deterrent opioid analgesic in rats

Loading next page...
 
/lp/springer_journal/effects-of-nalfurafine-on-the-reinforcing-thermal-antinociceptive-and-F1d6PeGeko
Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Subject
Biomedicine; Neurosciences; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
D.O.I.
10.1007/s00213-017-4652-3
Publisher site
See Article on Publisher Site

Abstract

Psychopharmacology (2017) 234:2597–2605 DOI 10.1007/s00213-017-4652-3 ORIGINAL INVESTIGATION Effects of nalfurafine on the reinforcing, thermal antinociceptive, and respiratory-depressant effects of oxycodone: modeling an abuse-deterrent opioid analgesic in rats 1,2 3 4 5 E. Andrew Townsend & Jennifer E. Naylor & S. Stevens Negus & Shelley R. Edwards & 5 6 7,8 Hina N. Qureshi & Hunter W. McLendon & Christopher R. McCurdy & 7 9 9 9 Coco N. Kapanda & Jussara M. do Carmo & Fernanda S. da Silva & John E. Hall & 10 2 Kenneth J. Sufka & Kevin B. Freeman Received: 18 April 2017 /Accepted: 19 May 2017 /Published online: 31 May 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract effect functions were each determined for oxycodone, Rationale Strategies to reduce the misuse of mu opioid ago- nalfurafine, and the same oxycodone/nalfurafine mixture pro- nists are critically needed. Previous work has shown that kap- portions. Finally, the respiratory-depressant effects of equi- pa opioid agonists can diminish the abuse-related effects and antinociceptive doses of oxycodone, nalfurafine, and the mix- augment the antinociceptive effects of mu agonists. However, tures were compared. use of traditional kappa agonists is limited by their dysphoric Results Nalfurafine decreased the reinforcing effects of oxy- side

Journal

PsychopharmacologySpringer Journals

Published: May 31, 2017

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off