Effects of montelukast on tendon healing in a murine model

Effects of montelukast on tendon healing in a murine model Eur J Plast Surg (2017) 40:171–176 DOI 10.1007/s00238-017-1283-1 EXPERIMENTAL STUDY 1 2 3 2 Kaan Gideroğlu & Hüsamettin Çakıcı & Onur Hapa & Kutay E. Özturan & 4 5 6 Ergun Bozdağ & Fahri Yılmaz & İbrahim Sağlam Received: 22 July 2016 /Accepted: 22 January 2017 /Published online: 8 March 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract the experimental group that received montelukast sodium Background Tendon injury induces a local inflammatory re- (p < 0.05). In terms of the formation of collagen, no significant sponse characterized by the production of pro-inflammatory difference was observed between the groups in the second and cytokines. The aim of this study is to investigate the effects of fourth weeks. Tendon breaking loads were 33.2 ± 10.95 and montelukast sodium on the healing of tendons through histo- 38.8 ± 10.90 N for the montelukast group and the control group, logical and biomechanical evaluations. respectively. However, the difference between the groups was Methods Forty-eight female Wistar albino rats were randomly found to be statistically insignificant (p > 0.05). assigned to an experimental group that received montelukast Conclusions There was no negative effect on the healing of sodium (n = 24) and a control group (n = http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Plastic Surgery Springer Journals

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Springer Berlin Heidelberg
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Medicine & Public Health; Plastic Surgery
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