Int Urol Nephrol (2017) 49:1561–1567 DOI 10.1007/s11255-017-1640-9 UROLOGY - ORIGINAL PAPER Effects of long‑term treatment with haloperidol, clozapine and aripiprazole on mice isolated vas deferens 1 2 2 Mehmet Hanifi Tanyeri · Mehmet Emin Buyukokuroglu · Pelin Tanyeri · 3 3 3 3 Oguz Mutlu · Füruzan Yildiz Akar · Güner Ulak · Bekir Faruk Erden Received: 24 January 2017 / Accepted: 19 June 2017 / Published online: 3 July 2017 © Springer Science+Business Media B.V. 2017 Abstract of haloperidol, clozapine and aripiprazole on the contrac- Purpose Sexual dysfunction is a common condition in tion of the vas deferens. patients taking antipsychotics and is the most bothersome Methods Male inbred BALB/c ByJ mice aged 7 weeks symptom and adverse drug effect, resulting in a negative upon arrival to the laboratory were used in this study. Halo- effect on treatment compliance. Pharmacology research peridol, clozapine, aripiprazole, serotonin, noradrenaline, into human ejeculatory disorders is limited to clinical stud- ATP and KCl were dissolved in 0.9% physiological saline. ies with registered drugs affecting the ejaculation process; The mice were randomly divided into experimental groups therefore, animal research has become the need. We aimed as follows: saline; haloperidol 0.125 mg/kg; haloperi- to investigate
International Urology and Nephrology – Springer Journals
Published: Jul 3, 2017
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