Psychopharmacology (2017) 234:2683–2696 DOI 10.1007/s00213-017-4660-3 ORIGINAL INVESTIGATION Effects of ketamine on the unconditioned and conditioned locomotor activity of preadolescent and adolescent rats: impact of age, sex, and drug dose 1 1 1 Sanders A. McDougall & Andrea E. Moran & Timothy J. Baum & 1 1 Matthew G. Apodaca & Vanessa Real Received: 12 January 2017 /Accepted: 21 May 2017 /Published online: 7 June 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract ability to both enhance DA neurotransmission and antagonize Rationale Ketamine is used by preadolescent and adolescent N-methyl-D-aspartate (NMDA) receptors. Additional re- humans for licit and illicit purposes. search will be necessary to parse out the relative contributions Objective The goal of the present study was to determine the of DA and NMDA system functioning when assessing the effects of acute and repeated ketamine treatment on the un- behavioral effects of ketamine during early ontogeny. conditioned behaviors and conditioned locomotor activity of preadolescent and adolescent rats. . . . Keywords Ketamine Cocaine Locomotor activity Methods To assess unconditioned behaviors, female and male . . Conditioned activity Preadolescent rats Adolescent rats rats were injected with ketamine (5–40 mg/kg), and distance traveled was measured on postnatal day (PD) 21–25 or PD 41–45.
Psychopharmacology – Springer Journals
Published: Jun 7, 2017
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