Effects of mutations rad201, mei-9, and mei-41on cell sensitivity to gamma-radiation in Drosophilaoogenesis were studied. Females of the control (Oregon R) and mutant strains were irradiated at a dose of 15 Gy. For 9 days after the irradiation, the number of eggs in consecutive day batches, the frequency of dominant lethals (DLs) among the eggs, and the cytologically recorded distribution of oocytes for stages of their development, and the frequency of egg chamber degeneration in female ovaries were estimated. As a result of joint analysis of the data, different oogenesis stages were characterized with regard to the frequency of two radiation-induced events: appearance of DLs in oocytes and degeneration of egg chambers due to apoptosis of nurse cells. It was shown that the mutations affect these parameters only at particular stages of early oogenesis, at which previtellogenetic growth of egg follicles and meiotic recombination in oocytes occur. Mutation rad201 G1increased the frequency of DLs and egg chamber degeneration, mei-41 D5affected only the DL frequency, and mei-9 a, in addition to enhancing the chamber degeneration frequency, promoted radiation “rescue” of some oocytes from the DL induction.
Russian Journal of Genetics – Springer Journals
Published: Oct 16, 2004
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