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U. Ehling, J. Favor, J. Kratochvílová, A. Neuhäuser-Klaus (1982)
Dominant cataract mutations and specific-locus mutations in mice induced by radiation or ethylnitrosourea.Mutation research, 92 1-2
Jack Favor, A. Neuhäuser-Klaus, U. Ehling (1988)
The effect of dose fractionation on the frequency of ethylnitrosourea-induced dominant cataract and recessive specific locus mutations in germ cells of the mouse.Mutation research, 198 2
W. Russell, E. Kelly, P. Hunsicker, J. Bangham, S. Maddux, E. Phipps (1979)
Specific-locus test shows ethylnitrosourea to be the most potent mutagen in the mouse.Proceedings of the National Academy of Sciences of the United States of America, 76 11
A. Davis, R. Woychik, M. Justice (1999)
Effective chemical mutagenesis in FVB/N mice requires low doses of ethylnitrosoureaMammalian Genome, 10
A. Kasarskis, K. Manova, K. Anderson (1998)
A phenotype-based screen for embryonic lethal mutations in the mouse.Proceedings of the National Academy of Sciences of the United States of America, 95 13
F. Johnson, Susan LEWISt (1981)
Electrophoretically detected germinal mutations induced in the mouse by ethylnitrosourea.Proceedings of the National Academy of Sciences of the United States of America, 78 5
E. Rinchik, Donald Carpenter, P. Selby (1990)
A strategy for fine-structure functional analysis of a 6- to 11-centimorgan region of mouse chromosome 7 by high-efficiency mutagenesis.Proceedings of the National Academy of Sciences of the United States of America, 87
W. Russell, P. Hunsicker, D. Carpenter, C. Cornett, G. Guinn (1982)
Effect of dose fractionation on the ethylnitrosourea induction of specific-locus mutations in mouse spermatogonia.Proceedings of the National Academy of Sciences of the United States of America, 79 11
E. Rinchik, D. Carpenter, M. Handel (1995)
Pleiotropy in microdeletion syndromes: neurologic and spermatogenic abnormalities in mice homozygous for the p6H deletion are likely due to dysfunction of a single gene.Proceedings of the National Academy of Sciences of the United States of America, 92 14
V. Bode (1984)
Ethylnitrosourea mutagenesis and the isolation of mutant alleles for specific genes located in the T region of mouse chromosome 17.Genetics, 108 2
A. Shedlovsky, T. King, W. Dove (1988)
Saturation germ line mutagenesis of the murine t region including a lethal allele at the quaking locus.Proceedings of the National Academy of Sciences of the United States of America, 85 1
A. Shedlovsky, J. McDonald, D. Symula, W. Dove (1993)
Mouse models of human phenylketonuria.Genetics, 134 4
Jack Favor, A. Neuhäuser-Klaus, U. Ehling, Andrea Wulff, A. Zeeland (1997)
The effect of the interval between dose applications on the observed specific-locus mutation rate in the mouse following fractionated treatments of spermatogonia with ethylnitrosourea.Mutation research, 374 2
P. Nolan, D. Kapfhamer, M. Bucan (1997)
Random mutagenesis screen for dominant behavioral mutations in mice.Methods, 13 4
W. Russell, P. Hunsicker, G. Raymer, M. Steele, K. Stelzner, H. Thompson (1982)
Dose--response curve for ethylnitrosourea-induced specific-locus mutations in mouse spermatogonia.Proceedings of the National Academy of Sciences of the United States of America, 79 11
A. Shedlovsky, J. Guénet, L. Johnson, W. Dove (1986)
Induction of recessive lethal mutations in the T/t-H-2 region of the mouse genome by a point mutagen.Genetical research, 47 2
J. Peters, S. Andrews, J. Loutit, J. Clegg (1985)
A mouse beta-globin mutant that is an exact model of hemoglobin Rainier in man.Genetics, 110 4
M. Justice, V. Bode (1986)
Induction of new mutations in a mouse t-haplotype using ethylnitrosourea mutagenesis.Genetical research, 47 3
S. Hitotsumachi, D. Carpenter, W. Russell (1985)
Dose-repetition increases the mutagenic effectiveness of N-ethyl-N-nitrosourea in mouse spermatogonia.Proceedings of the National Academy of Sciences of the United States of America, 82 19
S. Cordes, G. Barsh (1994)
The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factorCell, 79
(1998)
An Oak Ridge legacy: the specific locus test and its role in mouse mutagenesis.
J. Favor, A. Neuhäuser-Klaus, U. Ehling (1991)
The induction of forward and reverse specific-locus mutations and dominant cataract mutations in spermatogonia of treated strain DBA/2 mice by ethylnitrosourea.Mutation research, 249 2
A. Moser, H. Pitot, W. Dove (1990)
A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse.Science, 247 4940
The germline supermutagen, N-ethyl-N-nitrosourea (ENU), has a variety of effects on mice. ENU is a toxin and carcinogen as well as a mutagen, and strains differ in their susceptibility to its effects. Therefore, it is necessary to determine an appropriate mutagenic, non-toxic dose of ENU for strains that are to be used in experiments. In order to provide some guidance, we have compiled data from a number of laboratories that have exposed male mice from inbred and non-inbred strains or their F1 hybrids to ENU. The results show that most F1 hybrid animals tolerate ENU well, but that inbred strains of mice vary in their longevity and in their ability to recover fertility after treatment with ENU.
Mammalian Genome – Springer Journals
Published: Feb 25, 2014
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