Effects of allitridin on acute and chronic mouse cytomegalovirus infection

Effects of allitridin on acute and chronic mouse cytomegalovirus infection This study investigated the effects of allitridin on acute and chronic mouse cytomegalovirus (MCMV) infections in vivo . The results demonstrated that allitridin reduced the titers of MCMV in salivary glands, and reductions in viral loads were confirmed by determining viral DNA and RNA levels in susceptible organs during the acute infection phase. Although allitridin did not eliminate MCMV, treatment reduced viral levels and facilitated healing of pathologic lesions in organs, particularly during the chronic infection phase. The results presented in this report suggest that allitridin could act as an effective agent against MCMV infections in vivo . http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Effects of allitridin on acute and chronic mouse cytomegalovirus infection

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Publisher
Springer Vienna
Copyright
Copyright © 2011 by Springer-Verlag
Subject
Biomedicine; Virology; Infectious Diseases; Medical Microbiology
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-011-1025-9
Publisher site
See Article on Publisher Site

Abstract

This study investigated the effects of allitridin on acute and chronic mouse cytomegalovirus (MCMV) infections in vivo . The results demonstrated that allitridin reduced the titers of MCMV in salivary glands, and reductions in viral loads were confirmed by determining viral DNA and RNA levels in susceptible organs during the acute infection phase. Although allitridin did not eliminate MCMV, treatment reduced viral levels and facilitated healing of pathologic lesions in organs, particularly during the chronic infection phase. The results presented in this report suggest that allitridin could act as an effective agent against MCMV infections in vivo .

Journal

Archives of VirologySpringer Journals

Published: Oct 1, 2011

References

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